Prdx4 peroxiredoxin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prdx4provided by RGD
Official Full Name: peroxiredoxin 4provided by RGD
Primary source: RGD:620043
See related: EnsemblRapid:ENSRNOG00000003763 AllianceGenome:RGD:620043
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including identical protein binding activity; molecular sequestering activity; and thioredoxin peroxidase activity. Predicted to be involved in cell redox homeostasis; hydrogen peroxide catabolic process; and response to oxidative stress. Predicted to act upstream of or within several processes, including negative regulation of male germ cell proliferation; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and protein maturation by protein folding. Located in extracellular space and smooth endoplasmic reticulum. Orthologous to human PRDX4 (peroxiredoxin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 657.7), Testes (RPKM 250.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (43876374..43893815)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (40026762..40044066)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (43495453..43512994)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the rough endoplasmic reticulum, Prx-4 interacts with and is located with STIM1 in liver microsomes.
Title: Evidence for the interaction of peroxiredoxin-4 with the store-operated calcium channel activator STIM1 in liver cells.
The regulatory effects of PRDX4 on IL-1beta-induced chondrocyte apoptosis.
Title: Peroxiredoxin 4 inhibits IL-1β-induced chondrocyte apoptosis via PI3K/AKT signaling.
Our data suggested that reactive oxygen species, at least in part, play a role in cancer metastatic pain development and persistency which can be attenuated by the adminstration of recombinant PTD-Cu/Zn SOD via the peroxiredoxin 4 modulation from oxidative stress.
Title: Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation.
Biochemical characterization of the purified two N-terminally truncated mutants of peroxiredoxin 4 showed that the truncated enzymes are enzymatically active and form an oligomeric structure.
Title: Expression of N-terminally truncated forms of rat peroxiredoxin-4 in insect cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA819406 (e-PCR)
- UniSTS:261666

Prdx4 (e-PCR), detects polymorphism
- UniSTS:525995

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular sequestering activity	IEA Inferred from Electronic Annotation more info
enables molecular sequestering activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxiredoxin activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell redox homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of male germ cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of male germ cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline	ISO Inferred from Sequence Orthology more info
involved_in protein maturation by protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein maturation by protein folding	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in smooth endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peroxiredoxin-4

Names: antioxidant enzyme AOE372; peroxiredoxin IV; prx-IV; thioredoxin peroxidase AO372; thioredoxin-dependent peroxide reductase A0372; thioredoxin-dependent peroxiredoxin 4

NP_445964.1

EC 1.11.1.24

XP_006257013.1

EC 1.11.1.24

XP_017457660.1

EC 1.11.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053512.2 → NP_445964.1 peroxiredoxin-4 precursor

See identical proteins and their annotated locations for NP_445964.1

Status: PROVISIONAL

Source sequence(s)

AF106945

UniProtKB/Swiss-Prot

Q9Z0V5

UniProtKB/TrEMBL

A6IPQ9

Related

ENSRNOP00000005014.5, ENSRNOT00000005014.6

Conserved Domains (2) summary

COG0450
Location:83 → 271

AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]

cd03015
Location:83 → 254

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

43876374..43893815

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256951.5 → XP_006257013.1 peroxiredoxin-4 isoform X1

UniProtKB/TrEMBL

A0A8I6AER1

Related

ENSRNOP00000086837.1, ENSRNOT00000105854.2

Conserved Domains (2) summary

COG0450
Location:65 → 255

AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]

cd03015
Location:67 → 238

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
XM_017602171.3 → XP_017457660.1 peroxiredoxin-4 isoform X2

UniProtKB/TrEMBL

A0A8L2Q1B0

Related

ENSRNOP00000080648.1, ENSRNOT00000114432.2