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    LCE3C late cornified envelope 3C [ Homo sapiens (human) ]

    Gene ID: 353144, updated on 27-Nov-2024

    Summary

    Official Symbol
    LCE3Cprovided by HGNC
    Official Full Name
    late cornified envelope 3Cprovided by HGNC
    Primary source
    HGNC:HGNC:16612
    See related
    Ensembl:ENSG00000244057 MIM:612615; AllianceGenome:HGNC:16612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LEP15; SPRL3A
    Summary
    Involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and killing of cells of another organism. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LCE3C in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152600234..152601086)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (151736788..151737640)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152572710..152573562)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene late cornified envelope 3E Neighboring gene late cornified envelope 3D Neighboring gene late cornified envelope 3B Neighboring gene late cornified envelope 3A

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of late cornified envelope 3C (LCE3C) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    late cornified envelope protein 3C
    Names
    late envelope protein 15
    small proline rich-like (epidermal differentiation complex) 3A
    small proline-rich-like epidermal differentiation complex protein 3A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178434.3NP_848521.1  late cornified envelope protein 3C

      See identical proteins and their annotated locations for NP_848521.1

      Status: VALIDATED

      Source sequence(s)
      AL356426
      Consensus CDS
      CCDS1015.1
      UniProtKB/Swiss-Prot
      A1L420, Q5T5A8
      Related
      ENSP00000507204.1, ENST00000684028.1
      Conserved Domains (1) summary
      pfam14672
      Location:2594
      LCE; Late cornified envelope

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      152600234..152601086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      151736788..151737640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)