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    T01G9.2 PHAF1 protein T01G9.2 [ Caenorhabditis elegans ]

    Gene ID: 172609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T01G9.2
    Official Full Name
    PHAF1 protein T01G9.2
    Primary source
    WormBase:WBGene00011344
    Locus tag
    CELE_T01G9.2
    See related
    AllianceGenome:WB:WBGene00011344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in Golgi to plasma membrane protein transport. Located in striated muscle dense body. Orthologous to human PHAF1 (phagosome assembly factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T01G9.2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (8275665..8288124, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene NAM-associated domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ZP domain-containing protein Neighboring gene LRRCT domain-containing protein Neighboring gene Casein kinase II subunit beta Neighboring gene Nuclear pore complex protein Nup85

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals. Franco-Romero A, et al. J Clin Invest, 2024 Jun 13. PMID 38869949, Free PMC Article
    2. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    3. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals.
      Title: C16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in striated muscle dense body HDA PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PHAF1 protein T01G9.2
    NP_492252.1
    • Confirmed by transcript evidence
    NP_740894.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8275665..8288124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059851.6 → NP_492252.1  PHAF1 protein T01G9.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492252.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34692
      Conserved Domains (1) summary
      pfam03676
      Location:30 → 413
      UPF0183; uncharacterized protein family (UPF0183)

    2. NM_171841.9 → NP_740894.1  PHAF1 protein T01G9.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740894.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34692, Q22076, Q9U383
      Conserved Domains (1) summary
      pfam03676
      Location:33 → 416
      UPF0183; uncharacterized protein family (UPF0183)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34692.3

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