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    ola-1 Obg-like ATPase 1 [ Caenorhabditis elegans ]

    Gene ID: 173205, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ola-1
    Official Full Name
    Obg-like ATPase 1
    Primary source
    WormBase:WBGene00012344
    Locus tag
    CELE_W08E3.3
    See related
    AllianceGenome:WB:WBGene00012344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP hydrolysis activity. Involved in behavioral response to starvation; thermosensory behavior; and thermotaxis. Located in endoplasmic reticulum. Is expressed in anal depressor muscle; hypodermis; intestine; nervous system; and pharyngeal muscle cell. Orthologous to human OLA1 (Obg like ATPase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ola-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (13340327..13343952)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene putative small nuclear ribonucleoprotein-associated protein B Neighboring gene WW domain-containing protein Neighboring gene WW domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans. Aoki I, et al. PLoS Genet, 2022 Jun. PMID 35675262, Free PMC Article
    2. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal large subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in behavioral response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thermotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 

    General protein information

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    Preferred Names
    Obg-like ATPase 1
    NP_001252138.1
    • Confirmed by transcript evidence
    NP_001254006.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13340327..13343952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267077.3 → NP_001254006.1  Obg-like ATPase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254006.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E2JL06, P91917
      Conserved Domains (3) summary
      cd01900
      Location:24 → 300
      YchF; YchF GTPase
      PTZ00258
      Location:1 → 386
      PTZ00258; GTP-binding protein; Provisional
      pfam06071
      Location:302 → 385
      YchF-GTPase_C; Protein of unknown function (DUF933)

    2. NM_001265209.3 → NP_001252138.1  Obg-like ATPase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2JL06
      Conserved Domains (1) summary
      PTZ00258
      Location:2 → 116
      PTZ00258; GTP-binding protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91917.1

    Gene LinkOut

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