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    alg-4 Putative protein tag-76 [ Caenorhabditis elegans ]

    Gene ID: 176400, updated on 2-Nov-2024

    Summary

    Official Symbol
    alg-4
    Official Full Name
    Putative protein tag-76
    Primary source
    WormBase:WBGene00006449
    Locus tag
    CELE_ZK757.3
    See related
    AllianceGenome:WB:WBGene00006449
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA endonuclease activity; miRNA binding activity; and single-stranded RNA binding activity. Involved in spermatogenesis. Predicted to be located in P granule. Predicted to be part of RISC complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in male. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See alg-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (9887210..9891424, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Snake toxin/toxin-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MAM domain-containing protein Neighboring gene ncRNA Neighboring gene ubiquitinyl hydrolase 1

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of RISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Putative protein tag-76
    NP_499191.1
    • Confirmed by transcript evidence
    NP_499192.1
    • Confirmed by transcript evidence
    NP_499193.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9887210..9891424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066790.5NP_499191.1  Putative protein tag-76 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34681, Q7JMT0, Q9TW94
      Conserved Domains (5) summary
      PLN03202
      Location:67959
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:374484
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:530964
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:266306
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:89235
      ArgoN; N-terminal domain of argonaute
    2. NM_066791.6NP_499192.1  Putative protein tag-76 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499192.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34681
      Conserved Domains (5) summary
      PLN03202
      Location:64956
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:371481
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:527961
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:263303
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:86232
      ArgoN; N-terminal domain of argonaute
    3. NM_066792.4NP_499193.1  Putative protein tag-76 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499193.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34681