U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sym-1 Leucine-rich repeat-containing protein let-4 [ Caenorhabditis elegans ]

    Gene ID: 181555, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sym-1
    Official Full Name
    Leucine-rich repeat-containing protein let-4
    Primary source
    WormBase:WBGene00006366
    Locus tag
    CELE_C44H4.3
    See related
    AllianceGenome:WB:WBGene00006366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in extracellular space. Is expressed in vulB1 and vulB2. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sym-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (14581622..14584378)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Chorein N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Leucine-rich repeat-containing protein let-4 Neighboring gene ncRNA Neighboring gene TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. C. elegans sym-1 is a downstream target of the hunchback-like-1 developmental timing transcription factor. Niwa R, et al. Cell Cycle, 2009 Dec 15. PMID 19923914, Free PMC Article
    2. The apical ECM preserves embryonic integrity and distributes mechanical stress during morphogenesis. Vuong-Brender TTK, et al. Development, 2017 Dec 1. PMID 28526752, Free PMC Article
    3. Extracellular leucine-rich repeat proteins are required to organize the apical extracellular matrix and maintain epithelial junction integrity in C. elegans. Mancuso VP, et al. Development, 2012 Mar. PMID 22278925, Free PMC Article
    4. A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis. Ito TK, et al. PLoS One, 2014. PMID 25057989, Free PMC Article
    5. The identities of sym-2, sym-3 and sym-4, three genes that are synthetically lethal with mec-8 in Caenorhabditis elegans. Yochem J, et al. Genetics, 2004 Nov. PMID 15579686, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Leucine-rich repeat-containing protein let-4
    NP_510426.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14581622..14584378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078025.7 → NP_510426.1  Leucine-rich repeat-containing protein let-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFP4
      Conserved Domains (5) summary
      cd00116
      Location:81 → 384
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:399 → 410
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:86 → 108
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13306
      Location:74 → 208
      LRR_5; Leucine rich repeats (6 copies)
      pfam13855
      Location:253 → 313
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools