dis-3 putative exosome complex exonuclease RRP44 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dis-3
Official Full Name: putative exosome complex exonuclease RRP44
Primary source: WormBase:WBGene00001001
Locus tag: CELE_C04G2.6
See related: AllianceGenome:WB:WBGene00001001
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3'-5'-RNA exonuclease activity and endonuclease activity. Predicted to be involved in nuclear mRNA surveillance of mRNA 3'-end processing and rRNA catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in several structures, including anal depressor muscle; excretory cell; hypodermis; nervous system; and reproductive system. Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dis-3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 13

Sequence:: Chromosome: IV; NC_003282.8 (10097202..10106523)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C04G2.4 (e-PCR)
- UniSTS:320839

C04G2.6 (e-PCR)
- UniSTS:308925

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA nuclease activity	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nuclear mRNA surveillance of mRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cytoplasmic exosome (RNase complex)	IBA Inferred from Biological aspect of Ancestor more info
part_of exosome (RNase complex)	IEA Inferred from Electronic Annotation more info
part_of nuclear exosome (RNase complex)	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative exosome complex exonuclease RRP44

NP_501835.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10097202..10106523

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069434.6 → NP_501835.2 putative exosome complex exonuclease RRP44 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501835.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17632

Conserved Domains (3) summary

TIGR00358
Location:271 → 940

3_prime_RNase; VacB and RNase II family 3'-5' exoribonucleases

pfam00773
Location:479 → 809

RNB; RNB domain

cl14812
Location:21 → 202

PIN_SF; PIN (PilT N terminus) domain: Superfamily