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    sel-5 Serine/threonine-protein kinase sel-5 [ Caenorhabditis elegans ]

    Gene ID: 175599, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sel-5
    Official Full Name
    Serine/threonine-protein kinase sel-5
    Primary source
    WormBase:WBGene00004762
    Locus tag
    CELE_F35G12.3
    See related
    AllianceGenome:WB:WBGene00004762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Predicted to be involved in positive regulation of Notch signaling pathway and regulation of clathrin-dependent endocytosis. Predicted to be active in cytoplasm. Is expressed in reproductive system. Used to study Parkinson's disease. Orthologous to several human genes including AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sel-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    17
    Sequence:
    Chromosome: III; NC_003281.10 (4571764..4578437, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Isocitrate dehydrogenase [NAD] subunit, mitochondrial Neighboring gene ncRNA Neighboring gene WD repeat-containing protein 48 homolog Neighboring gene 26S proteasome non-ATPase regulatory subunit 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity. Knop F, et al. Elife, 2024 Jul 19. PMID 39028260, Free PMC Article
    2. SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans. Fares H, et al. Genetics, 1999 Dec. PMID 10581273, Free PMC Article
    3. Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans. Tax FE, et al. Genetics, 1997 Dec. PMID 9409830, Free PMC Article
    4. New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme. Katic I, et al. Genetics, 2005 Dec. PMID 16157663, Free PMC Article
    5. A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode. Tsushima H, et al. PLoS One, 2013. PMID 23424658, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity.
      Title: Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables AP-2 adaptor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase sel-5
    NP_001022562.1
    • Confirmed by transcript evidence
    NP_001022563.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4571764..4578437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027391.9 → NP_001022562.1  Serine/threonine-protein kinase sel-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022562.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECQ3, G5EFY9
      Conserved Domains (2) summary
      smart00220
      Location:48 → 310
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:43 → 320
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    2. NM_001027392.6 → NP_001022563.1  Serine/threonine-protein kinase sel-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022563.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECQ3
      Conserved Domains (2) summary
      smart00220
      Location:48 → 310
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:43 → 320
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECQ3.1

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