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    mfn-1 Mitoferrin [ Caenorhabditis elegans ]

    Gene ID: 174752, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mfn-1
    Official Full Name
    Mitoferrin
    Primary source
    WormBase:WBGene00012204
    Locus tag
    CELE_W02B12.9
    See related
    AllianceGenome:WB:WBGene00012204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial membrane. Is expressed in intestine and nervous system. Orthologous to several human genes including SLC25A28 (solute carrier family 25 member 28). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mfn-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (11470003..11472016, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase-activating protein 68F;Rho-GAP domain-containing protein Neighboring gene Kinesin motor domain-containing protein Neighboring gene CDGSH iron-sulfur domain-containing protein 2 homologue;Iron-binding zinc finger CDGSH type domain-containing protein Neighboring gene tRNA (guanine-N(7)-)-methyltransferase Neighboring gene Beta-1,4-N-acetylgalactosaminyltransferase Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitoferrin-1 is Involved in the Progression of Alzheimer's Disease Through Targeting Mitochondrial Iron Metabolism in a Caenorhabditis elegans Model of Alzheimer's Disease. Huang J, et al. Neuroscience, 2018 Aug 10. PMID 29908215
    2. Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans. Ren Y, et al. PLoS One, 2012. PMID 22253756, Free PMC Article
    3. The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans. Ren Y, et al. Exp Gerontol, 2015 May. PMID 25769692
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduced mitoferrin levels in C. elegans by RNA interference treatment causes pleiotropic phenotypes such as small body size, reduced fecundity, slow movement and increased sensitivity to paraquat.
      Title: Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans.
    2. These results confirm that knockdown of mitoferrin-1 can slow the progress of disease in Alzheimer model of C. elegans and suggest that mitoferrin-1 plays a major role in mediating mitochondrial iron metabolism in this process.
      Title: Mitoferrin-1 is Involved in the Progression of Alzheimer's Disease Through Targeting Mitochondrial Iron Metabolism in a Caenorhabditis elegans Model of Alzheimer's Disease.
    3. The GCN-2 pathway was not required for the longevity phenotype of mfn-1 worms.
      Title: The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mitoferrin
    NP_001382726.1
    • Partially confirmed by transcript evidence
    NP_001391079.1
    • Partially confirmed by transcript evidence
    NP_001391080.1
    • Partially confirmed by transcript evidence
    NP_496447.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11470003..11472016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064046.7 → NP_496447.1  Mitoferrin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496447.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23125
      Conserved Domains (1) summary
      pfam00153
      Location:14 → 108
      Mito_carr; Mitochondrial carrier protein

    2. NM_001404239.1 → NP_001391079.1  Mitoferrin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8D9I609

    3. NM_001404240.1 → NP_001391080.1  Mitoferrin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8D9I610

    4. NM_001395808.1 → NP_001382726.1  Mitoferrin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8D9I8L7
      Conserved Domains (1) summary
      PTZ00168
      Location:22 → 193
      PTZ00168; mitochondrial carrier protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23125.1

    Gene LinkOut

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