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    icp-1 Inner centromere protein ARK-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171788, updated on 9-Dec-2024

    Summary

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    Official Symbol
    icp-1
    Official Full Name
    Inner centromere protein ARK-binding domain-containing protein
    Primary source
    WormBase:WBGene00002047
    Locus tag
    CELE_Y39G10AR.13
    See related
    AllianceGenome:WB:WBGene00002047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein serine/threonine kinase activator activity. Involved in mitotic cytokinesis and nuclear division. Located in kinetochore and nucleus. Orthologous to human INCENP (inner centromere protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See icp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (2304513..2306790, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene TPR_MLP1_2 domain-containing protein Neighboring gene TPX2 domain-containing protein Neighboring gene Ectopic P granules protein 2 Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene 5-methylcytosine rRNA methyltransferase nsun-4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-resolution temporal analysis reveals a functional timeline for the molecular regulation of cytokinesis. Davies T, et al. Dev Cell, 2014 Jul 28. PMID 25073157, Free PMC Article
    2. Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity. Bishop JD, et al. J Biol Chem, 2002 Aug 2. PMID 12048181, Free PMC Article
    3. Tousled-mediated activation of Aurora B kinase does not require Tousled kinase activity in vivo. Riefler GM, et al. J Biol Chem, 2008 May 9. PMID 18334486, Free PMC Article
    4. Functional analysis of kinetochore assembly in Caenorhabditis elegans. Oegema K, et al. J Cell Biol, 2001 Jun 11. PMID 11402065, Free PMC Article
    5. CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1. Romano A, et al. J Cell Biol, 2003 Apr 28. PMID 12707312, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome movement towards spindle pole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Inner centromere protein ARK-binding domain-containing protein
    NP_001293363.1
    • Confirmed by transcript evidence
    NP_490956.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2304513..2306790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058555.9 → NP_490956.1  Inner centromere protein ARK-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490956.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE37
      Conserved Domains (2) summary
      PTZ00121
      Location:216 → 540
      PTZ00121; MAEBL; Provisional
      pfam03941
      Location:532 → 587
      INCENP_ARK-bind; Inner centromere protein, ARK binding region

    2. NM_001306434.3 → NP_001293363.1  Inner centromere protein ARK-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293363.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M920
      Conserved Domains (2) summary
      PTZ00121
      Location:165 → 489
      PTZ00121; MAEBL; Provisional
      pfam03941
      Location:481 → 536
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
    Nucleotide Protein
    Heading Accession and Version

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