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    cyld-1 ubiquitinyl hydrolase 1 [ Caenorhabditis elegans ]

    Gene ID: 176401, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyld-1
    Official Full Name
    ubiquitinyl hydrolase 1
    Primary source
    WormBase:WBGene00009594
    Locus tag
    CELE_F40F12.5
    See related
    AllianceGenome:WB:WBGene00009594
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable K63-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Predicted to be involved in protein K63-linked deubiquitination. Predicted to be located in centrosome; membrane; and perinuclear region of cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including arcade cell; pharyngeal cell; pharyngeal-intestinal valve; rectal gland cell; and spermatheca. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyld-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    17
    Sequence:
    Chromosome: III; NC_003281.10 (9898604..9910658, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative protein tag-76 Neighboring gene MAM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CCHC-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of the C. elegans cyld-1 gene reveals extensive similarity with its human homolog. Hadweh P, et al. PLoS One, 2018. PMID 29394249, Free PMC Article
    2. The tumour suppressor CYLD regulates the p53 DNA damage response. Fernández-Majada V, et al. Nat Commun, 2016 Aug 26. PMID 27561390, Free PMC Article
    3. MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans. Vérièpe-Salerno J, et al. Autophagy Rep, 2023 Nov 9. PMID 38510643, Free PMC Article
    4. Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Koyuncu S, et al. Nature, 2021 Aug. PMID 34321666, Free PMC Article
    5. An actin-based viscoplastic lock ensures progressive body-axis elongation. Lardennois A, et al. Nature, 2019 Sep. PMID 31462781, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitinyl hydrolase 1
    NP_001255045.1
    • Confirmed by transcript evidence
    NP_001255046.1
    • Confirmed by transcript evidence
    NP_001255047.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9898604..9910658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268116.3 → NP_001255045.1  ubiquitinyl hydrolase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255045.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JMS4
      Conserved Domains (2) summary
      smart01052
      Location:460 → 522
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:766 → 1121
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    2. NM_001268117.4 → NP_001255046.1  ubiquitinyl hydrolase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255046.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L266
      Conserved Domains (2) summary
      smart01052
      Location:208 → 270
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:514 → 869
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    3. NM_001268118.3 → NP_001255047.1  ubiquitinyl hydrolase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L265
      Conserved Domains (2) summary
      smart01052
      Location:150 → 212
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:456 → 811
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    Nucleotide Protein
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