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    fnip-2 UDENN FNIP1/2-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177012, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fnip-2
    Official Full Name
    UDENN FNIP1/2-type domain-containing protein
    Primary source
    WormBase:WBGene00020208
    Locus tag
    CELE_T04C4.1
    See related
    AllianceGenome:WB:WBGene00020208
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase inhibitor activity and protein-folding chaperone binding activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FNIP1 (folliculin interacting protein 1) and FNIP2 (folliculin interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fnip-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    13
    Sequence:
    Chromosome: IV; NC_003282.8 (2222828..2236978)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene P3 protein Neighboring gene Eukaryotic translation initiation factor 3 30 kDa subunit Neighboring gene ncRNA Neighboring gene protein of unknown function WSN domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UDENN FNIP1/2-type domain-containing protein
    NP_001023357.2
    • Confirmed by transcript evidence
    NP_001023358.2
    • Partially confirmed by transcript evidence
    NP_001033430.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2222828..2236978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028187.5 → NP_001023358.2  UDENN FNIP1/2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023358.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0I9
      Conserved Domains (2) summary
      pfam14637
      Location:338 → 559
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:677 → 854
      FNIP_C; Folliculin-interacting protein C-terminus

    2. NM_001028186.5 → NP_001023357.2  UDENN FNIP1/2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023357.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0I8
      Conserved Domains (2) summary
      pfam14637
      Location:399 → 620
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:738 → 950
      FNIP_C; Folliculin-interacting protein C-terminus

    3. NM_001038341.3 → NP_001033430.1  UDENN FNIP1/2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001033430.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4A572
    Nucleotide Protein
    Heading Accession and Version

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