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    • Showing Current items.

    cit-1.1 Cyclin-T1.1 [ Caenorhabditis elegans ]

    Gene ID: 176125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cit-1.1
    Official Full Name
    Cyclin-T1.1
    Primary source
    WormBase:WBGene00000507
    Locus tag
    CELE_F44B9.4
    See related
    AllianceGenome:WB:WBGene00000507
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of DNA-templated transcription, elongation and positive regulation of transcription by RNA polymerase II. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed widely. Orthologous to several human genes including CCNT1 (cyclin T1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cit-1.1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    15
    Sequence:
    Chromosome: III; NC_003281.10 (8005933..8009821, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene KH domain-containing protein C06G4.1 Neighboring gene putative G-protein coupled receptor C06G4.5 Neighboring gene Uncharacterized protein Neighboring gene Cyclin-T1.2 Neighboring gene Lipid droplet-regulating VLDL assembly factor AUP1 homolog Neighboring gene Protein lin-36

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation. Ghosh D, et al. Genetics, 2008 Jan. PMID 18202370, Free PMC Article
    2. Metazoan operons accelerate recovery from growth-arrested states. Zaslaver A, et al. Cell, 2011 Jun 10. PMID 21663799, Free PMC Article
    3. CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo. Shim EY, et al. Genes Dev, 2002 Aug 15. PMID 12183367, Free PMC Article
    4. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription, elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin-T1.1
    NP_001370392.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8005933..8009821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382928.1 → NP_001370392.1  Cyclin-T1.1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34425, Q8IG21, Q8IG22
      Conserved Domains (2) summary
      cd20539
      Location:165 → 263
      CYCLIN_CCNT_rpt2; second cyclin box found in cyclin-T (CCNT) family
      cl40454
      Location:19 → 160
      CYCLIN_SF; Cyclin box fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34425.1

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