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    fic-1 Protein adenylyltransferase fic-1 [ Caenorhabditis elegans ]

    Gene ID: 177990, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fic-1
    Official Full Name
    Protein adenylyltransferase fic-1
    Primary source
    WormBase:WBGene00014004
    Locus tag
    CELE_ZK593.8
    See related
    AllianceGenome:WB:WBGene00014004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables AMPylase activity. Involved in defense response to Gram-negative bacterium. Located in endoplasmic reticulum and nuclear envelope. Is expressed widely. Orthologous to human FICD (FIC domain protein adenylyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fic-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (10937454..10939934)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Sm domain-containing protein Neighboring gene Protein lgg;Protein lgg-2 Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Over-expression of the constitutive AMPylase FIC-1(E274G) does not deplete cellular ATP pools in C. elegans. Champion M, et al. MicroPubl Biol, 2021 Jun 25. PMID 34189425, Free PMC Article
    2. Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response. Truttmann MC, et al. Proc Natl Acad Sci U S A, 2017 Jan 10. PMID 28031489, Free PMC Article
    3. The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones. Truttmann MC, et al. PLoS Genet, 2016 May. PMID 27138431, Free PMC Article
    4. The AMPylase FIC-1 modulates TGF-β signaling in Caenorhabditis elegans. Hernandez-Lima MA, et al. Front Mol Neurosci, 2022. PMID 36504677, Free PMC Article
    5. Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction. Szewczyk NJ, et al. J Exp Biol, 2006 Oct. PMID 17023606

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We identify a link between FIC-1-mediated AMPylation and susceptibility to the pathogen Pseudomonas aeruginosa, establishing a connection between AMPylation and innate immunity in C. elegans
      Title: The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables AMPylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables AMPylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMPylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein adenylyltransferase fic-1
    NP_502036.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10937454..10939934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069635.6 → NP_502036.1  Protein adenylyltransferase fic-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502036.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23544
      Conserved Domains (4) summary
      COG3177
      Location:265 → 478
      COG3177; Fic family protein [Transcription]
      sd00006
      Location:180 → 210
      TPR; TPR repeat [structural motif]
      pfam02661
      Location:326 → 422
      Fic; Fic/DOC family
      pfam13414
      Location:146 → 212
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23544.2

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