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    C05G5.5 Metalloprotease TIKI homolog [ Caenorhabditis elegans ]

    Gene ID: 181571, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C05G5.5
    Official Full Name
    Metalloprotease TIKI homolog
    Primary source
    WormBase:WBGene00007351
    Locus tag
    CELE_C05G5.5
    See related
    AllianceGenome:WB:WBGene00007351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in negative regulation of Wnt signaling pathway and proteolysis. Predicted to be active in membrane. Orthologous to human TRABD2A (TraB domain containing 2A) and TRABD2B (TraB domain containing 2B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C05G5.5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (14756055..14761121, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Matrix-remodeling-associated protein 7 Neighboring gene ncRNA Neighboring gene Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Neighboring gene ncRNA Neighboring gene Carboxypeptidase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Metalloprotease TIKI homolog
    NP_001257247.1
    • Confirmed by transcript evidence
    NP_001257248.1
    • Confirmed by transcript evidence
    NP_001257249.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14756055..14761121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270318.3 → NP_001257247.1  Metalloprotease TIKI homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257247.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H9G2V6, H9G2V7, I6U4Y5, Q17678
      Conserved Domains (1) summary
      pfam01963
      Location:36 → 351
      TraB; TraB family

    2. NM_001270319.3 → NP_001257248.1  Metalloprotease TIKI homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257248.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17678
      Conserved Domains (1) summary
      pfam01963
      Location:34 → 228
      TraB; TraB family

    3. NM_001270320.1 → NP_001257249.1  Metalloprotease TIKI homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257249.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17678
      Conserved Domains (1) summary
      pfam01963
      Location:10 → 177
      TraB; TraB family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17678.6

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