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    prx-1 AAA+ ATPase domain-containing protein;Peroxisomal ATPase PEX1 [ Caenorhabditis elegans ]

    Gene ID: 181538, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prx-1
    Official Full Name
    AAA+ ATPase domain-containing protein;Peroxisomal ATPase PEX1
    Primary source
    WormBase:WBGene00004191
    Locus tag
    CELE_C11H1.4
    See related
    AllianceGenome:WB:WBGene00004191
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be involved in protein import into peroxisome matrix and protein unfolding. Predicted to be located in peroxisome. Predicted to be active in cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in Heimler syndrome 1; peroxisome biogenesis disorder 1A; and peroxisome biogenesis disorder 1B. Orthologous to human PEX1 (peroxisomal biogenesis factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See prx-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    24
    Sequence:
    Chromosome: X; NC_003284.9 (14313927..14326726)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Golgi pH regulator Neighboring gene RING-type E3 ubiquitin transferase Neighboring gene ncRNA Neighboring gene CRAL-TRIO domain-containing protein Neighboring gene ncRNA Neighboring gene DUF3456 domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans. Isermann K, et al. J Mol Biol, 2004 May 7. PMID 15099742
    2. RNA interference of peroxisome-related genes in C. elegans: a new model for human peroxisomal disorders. Petriv OI, et al. Physiol Genomics, 2002 Aug 14. PMID 12181365
    3. Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. Thieringer H, et al. J Cell Sci, 2003 May 1. PMID 12665560
    4. Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5. Kong J, et al. Nat Commun, 2020 Jan 29. PMID 31996685, Free PMC Article
    5. Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. Simmer F, et al. PLoS Biol, 2003 Oct. PMID 14551910, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into peroxisome matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein unfolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AAA+ ATPase domain-containing protein;Peroxisomal ATPase PEX1
    NP_001367171.1
    • Confirmed by transcript evidence
    NP_510386.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14313927..14326726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077985.7 → NP_510386.2  Peroxisomal ATPase PEX1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510386.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED99
      Conserved Domains (3) summary
      COG0464
      Location:511 → 938
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam09262
      Location:103 → 179
      PEX-1N; Peroxisome biogenesis factor 1, N-terminal
      cl38936
      Location:481 → 522
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001381145.1 → NP_001367171.1  AAA+ ATPase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A6ZJ67
      Conserved Domains (2) summary
      pfam17862
      Location:191 → 227
      AAA_lid_3; AAA+ lid domain
      cl38936
      Location:10 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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