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    psa-3 Transcriptional coregulator psa-3 [ Caenorhabditis elegans ]

    Gene ID: 181631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    psa-3
    Official Full Name
    Transcriptional coregulator psa-3
    Primary source
    WormBase:WBGene00009560
    Locus tag
    CELE_F39D8.2
    See related
    AllianceGenome:WB:WBGene00009560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables transcription coactivator binding activity. Involved in regulation of asymmetric cell division. Located in nucleus. Is expressed in several structures, including P1; P10; TL.aa; TR.aa; and hypodermal cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See psa-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (15407931..15419298)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Spaetzle domain-containing protein Neighboring gene Zinc metalloproteinase nas-13 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila. Bhambhani C, et al. PLoS Genet, 2014 Feb. PMID 24516405, Free PMC Article
    2. Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans. Arata Y, et al. Dev Cell, 2006 Jul. PMID 16824957
    3. Comprehensive analysis of animal TALE homeobox genes: new conserved motifs and cases of accelerated evolution. Mukherjee K, et al. J Mol Evol, 2007 Aug. PMID 17665086
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. nob-1/Hox, ceh-20/Pbx, and a Meis-related gene, psa-3, are required for asymmetric division of the T hypodermal cell.
      Title: Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transcriptional coregulator psa-3
    NP_001076765.2
    • Confirmed by transcript evidence
    NP_001076766.1
    • Confirmed by transcript evidence
    NP_001257263.1
    • Confirmed by transcript evidence
    NP_001300347.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15407931..15419298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083296.5 → NP_001076765.2  Transcriptional coregulator psa-3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3ASQ5, D5MNM8, G5EFB3, Q0G825
      Conserved Domains (1) summary
      pfam16493
      Location:92 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. NM_001083297.5 → NP_001076766.1  Transcriptional coregulator psa-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076766.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFB3
      Conserved Domains (1) summary
      pfam16493
      Location:58 → 118
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    3. NM_001270334.3 → NP_001257263.1  Transcriptional coregulator psa-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257263.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MNM8
      Conserved Domains (1) summary
      pfam16493
      Location:26 → 86
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    4. NM_001313418.3 → NP_001300347.1  Transcriptional coregulator psa-3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASQ5
    Nucleotide Protein
    Heading Accession and Version

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