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    • Showing Current items.

    isy-1 Protein isy-1 [ Caenorhabditis elegans ]

    Gene ID: 179524, updated on 9-Dec-2024

    Summary

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    Official Symbol
    isy-1
    Official Full Name
    Protein isy-1
    Primary source
    WormBase:WBGene00009966
    Locus tag
    CELE_F53B7.3
    See related
    AllianceGenome:WB:WBGene00009966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in regulation of primary miRNA processing. Located in nucleus. Is expressed in several structures, including hypodermis and intestine. Orthologous to human ISY1 (ISY1 splicing factor homolog) and ISY1-RAB43 (ISY1-RAB43 readthrough). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See isy-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (10999663..11000699, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene Activin_recp domain-containing protein Neighboring gene Low-density lipoprotein receptor domain class A Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans. Jiang W, et al. Elife, 2018 Apr 17. PMID 29664006, Free PMC Article
    2. Mimicking of splicing-related retinitis pigmentosa mutations in C. elegans allow drug screens and identification of disease modifiers. Kukhtar D, et al. Hum Mol Genet, 2020 Mar 27. PMID 31919495
    3. Proteomic analysis reveals CACN-1 is a component of the spliceosome in Caenorhabditis elegans. Doherty MF, et al. G3 (Bethesda), 2014 Jun 19. PMID 24948787, Free PMC Article
    4. LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans. Pandey T, et al. Cell Rep, 2024 Mar 26. PMID 38446666, Free PMC Article
    5. A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans. Xu T, et al. PLoS Genet, 2023 Feb. PMID 36763670, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in generation of catalytic spliceosome for second transesterification step IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in generation of catalytic spliceosome for second transesterification step IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 3'-splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of primary miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of post-spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein isy-1
    NP_505803.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10999663..11000699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073402.7 → NP_505803.1  Protein isy-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505803.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20716
      Conserved Domains (1) summary
      pfam06246
      Location:1 → 264
      Isy1; Isy1-like splicing family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20716.1

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