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    dhcr-7 7-dehydrocholesterol reductase [ Caenorhabditis elegans ]

    Gene ID: 181886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhcr-7
    Official Full Name
    7-dehydrocholesterol reductase
    Primary source
    WormBase:WBGene00007126
    Locus tag
    CELE_B0250.9
    See related
    AllianceGenome:WB:WBGene00007126
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 7-dehydrocholesterol reductase activity. Predicted to be involved in cholesterol biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Behcet's disease; Greenberg dysplasia; Pelger-Huet anomaly; Smith-Lemli-Opitz syndrome; and primary biliary cholangitis. Orthologous to several human genes including DHCR7 (7-dehydrocholesterol reductase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhcr-7 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (20480803..20485385, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class BC (Class B-like) Neighboring gene Serpentine Receptor, class BC (Class B-like)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 7-dehydrocholesterol reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    7-dehydrocholesterol reductase
    NP_507941.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20480803..20485385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075540.6 → NP_507941.2  7-dehydrocholesterol reductase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507941.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED82
      Conserved Domains (1) summary
      cl21511
      Location:81 → 457
      PEMT; Phospholipid methyltransferase
    Nucleotide Protein
    Heading Accession and Version

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