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    cbp-2 histone acetyltransferase [ Caenorhabditis elegans ]

    Gene ID: 186960, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cbp-2
    Official Full Name
    histone acetyltransferase
    Primary source
    WormBase:WBGene00010545
    Locus tag
    CELE_K03H1.10
    See related
    AllianceGenome:WB:WBGene00010545
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone acetyltransferase activity; metal ion binding activity; and transcription coregulator activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cbp-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (9923174..9924800)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene USP domain-containing protein Neighboring gene pseudo Neighboring gene Transthyretin-like protein 3 Neighboring gene Transthyretin-like protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Lundblad JR, et al. Nature, 1995 Mar 2. PMID 7870179
    2. The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress. Li TY, et al. Nat Aging, 2021 Feb. PMID 33718883, Free PMC Article
    3. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    4. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase
    NP_499201.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9923174..9924800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066800.5 → NP_499201.1  histone acetyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBG3
      Conserved Domains (2) summary
      pfam02135
      Location:23 → 99
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:166 → 242
      KIX; KIX domain
    Nucleotide Protein
    Heading Accession and Version

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