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    hpk-1 Homeodomain-interacting protein kinase 1 [ Caenorhabditis elegans ]

    Gene ID: 180695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hpk-1
    Official Full Name
    Homeodomain-interacting protein kinase 1
    Primary source
    WormBase:WBGene00001994
    Locus tag
    CELE_F20B6.8
    See related
    AllianceGenome:WB:WBGene00001994
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including autophagosome assembly; determination of adult lifespan; and response to heat. Located in nucleus. Is expressed in several structures, including gonad; hypodermal cell; intestine; neurons; and pharyngeal cell. Used to study Parkinson's disease. Orthologous to several human genes including HIPK1 (homeodomain interacting protein kinase 1); HIPK2 (homeodomain interacting protein kinase 2); and HIPK3 (homeodomain interacting protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hpk-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (4210571..4217290, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Homeodomain interacting protein kinase (HPK-1) is required in the soma for robust germline proliferation in C. elegans. Berber S, et al. Dev Dyn, 2013 Nov. PMID 23904186
    2. Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans. Berber S, et al. Sci Rep, 2016 Jan 21. PMID 26791749, Free PMC Article
    3. Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A. Raich WB, et al. Genetics, 2003 Feb. PMID 12618396, Free PMC Article
    4. Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons. Lazaro-Pena MI, et al. Elife, 2023 Jun 20. PMID 37338980, Free PMC Article
    5. The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans. Das R, et al. PLoS Genet, 2017 Oct. PMID 29036198, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These functions of HPK-1/HSF-1 undergo rapid down-regulation once animals reach reproductive maturity. We show that HPK-1 fortifies proteostasis and extends longevity by an additional independent mechanism: induction of autophagy.
      Title: The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeodomain-interacting protein kinase 1
    NP_741761.1
    • Partially confirmed by transcript evidence
    NP_741762.1
    • Confirmed by transcript evidence
    NP_741763.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4210571..4217290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171663.4 → NP_741762.1  Homeodomain-interacting protein kinase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741762.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQ70
      Conserved Domains (2) summary
      smart00220
      Location:122 → 458
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:122 → 458
      PKc_like; Protein Kinases, catalytic domain

    2. NM_171662.10 → NP_741761.1  Homeodomain-interacting protein kinase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741761.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19632, Q8MQ69, Q8MQ70
      Conserved Domains (2) summary
      smart00220
      Location:147 → 483
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:147 → 483
      PKc_like; Protein Kinases, catalytic domain

    3. NM_171664.7 → NP_741763.1  Homeodomain-interacting protein kinase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741763.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQ70
      Conserved Domains (2) summary
      smart00220
      Location:41 → 377
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:41 → 377
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MQ70.1

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