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    smp-2 Sema domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smp-2
    Official Full Name
    Sema domain-containing protein
    Primary source
    WormBase:WBGene00004890
    Locus tag
    CELE_D1037.2
    See related
    AllianceGenome:WB:WBGene00004890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in nematode male tail mating organ morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including inner labial neurons; intestinal cell; pharyngeal cell; ray; and sex organ. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to several human genes including SEMA6A (semaphorin 6A); SEMA6B (semaphorin 6B); and SEMA6C (semaphorin 6C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smp-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (3666490..3671700, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene DEgenerin Like Neighboring gene Ferritin Neighboring gene Ras-related protein Rab-8A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis in C. elegans. Ginzburg VE, et al. Development, 2002 May. PMID 11959817
    2. Semaphorin signaling restricts neuronal regeneration in C. elegans. Harreguy MB, et al. Front Cell Dev Biol, 2022. PMID 36325362, Free PMC Article
    3. mab-20 encodes Semaphorin-2a and is required to prevent ectopic cell contacts during epidermal morphogenesis in Caenorhabditis elegans. Roy PJ, et al. Development, 2000 Feb. PMID 10648234
    4. Caenorhabditis elegans PlexinA, PLX-1, interacts with transmembrane semaphorins and regulates epidermal morphogenesis. Fujii T, et al. Development, 2002 May. PMID 11959816
    5. Vulva morphogenesis involves attraction of plexin 1-expressing primordial vulva cells to semaphorin 1a sequentially expressed at the vulva midline. Dalpé G, et al. Development, 2005 Mar. PMID 15716342

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode male tail mating organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode male tail mating organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sema domain-containing protein
    NP_491197.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3666490..3671700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058796.6 → NP_491197.3  Sema domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491197.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TYS4
      Conserved Domains (2) summary
      smart00630
      Location:47 → 429
      Sema; semaphorin domain
      cl15693
      Location:390 → 478
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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