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    algn-14 UDP-N-acetylglucosamine transferase subunit ALG14 [ Caenorhabditis elegans ]

    Gene ID: 187398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    algn-14
    Official Full Name
    UDP-N-acetylglucosamine transferase subunit ALG14
    Primary source
    WormBase:WBGene00019725
    Locus tag
    CELE_M02B7.4
    See related
    AllianceGenome:WB:WBGene00019725
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in nuclear membrane. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 15. Orthologous to human ALG14 (ALG14 UDP-N-acetylglucosaminyltransferase subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See algn-14 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (3800872..3803426, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein Neighboring gene Osmotic avoidance abnormal protein 3 Neighboring gene Exonuclease domain-containing protein Neighboring gene ncRNA Neighboring gene FTH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. U12 type introns were lost at multiple occasions during evolution. Bartschat S, et al. BMC Genomics, 2010 Feb 11. PMID 20149226, Free PMC Article
    2. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of UDP-N-acetylglucosamine transferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine transferase subunit ALG14
    NP_001294286.1
    • Confirmed by transcript evidence
    NP_001294287.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3800872..3803426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307357.2 → NP_001294286.1  UDP-N-acetylglucosamine transferase subunit ALG14 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294286.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PQW2
      Conserved Domains (1) summary
      pfam08660
      Location:45 → 213
      Alg14; Oligosaccharide biosynthesis protein Alg14 like

    2. NM_001307358.3 → NP_001294287.1  UDP-N-acetylglucosamine transferase subunit ALG14 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294287.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PE03
      Conserved Domains (1) summary
      pfam08660
      Location:45 → 227
      Alg14; Oligosaccharide biosynthesis protein Alg14 like
    Nucleotide Protein
    Heading Accession and Version

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