dsh-2 DiSHevelled related [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dsh-2
Official Full Name: DiSHevelled related
Primary source: WormBase:WBGene00001102
Locus tag: CELE_C27A2.6
See related: AllianceGenome:WB:WBGene00001102
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable frizzled binding activity. Involved in several processes, including Wnt signaling pathway, regulating spindle positioning; embryonic morphogenesis; and left/right axis specification. Located in cell cortex. Is expressed in several structures, including QL; QR; distal tip cell; nervous system; and somatic gonad precursor. Human ortholog(s) of this gene implicated in DiGeorge syndrome; autosomal dominant Robinow syndrome 2; autosomal dominant Robinow syndrome 3; and lung cancer. Orthologous to several human genes including DVL1 (dishevelled segment polarity protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dsh-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (5078233..5081174, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibiting von Hippel-Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism.
Title: Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism.
DSH-2 and MIG-5 regulate cell fate, beta-catenin nuclear levels and the polarity of beta-catenin regulation.
Title: Unique and redundant β-catenin regulatory roles of two Dishevelled paralogs during C. elegans asymmetric cell division.
DSH-2 function is necessary for the correct production of the embryonic ventral cord motor neurons.
Title: CWN-1 functions with DSH-2 to regulate C. elegans asymmetric neuroblast division in a beta-catenin independent Wnt pathway.
Either the DIX or DEP domain of DSH-2 is capable of activating the Wnt/beta-catenin asymmetry pathway and regulating anterior-posterior fate decisions required for proper morphogenesis.
Title: The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway.
DSH-2 functions as an upstream regulator of POP-1 in the somatic gonad to control asymmetric cell division, thereby establishing proximal-distal polarity of the developing organ
Title: DSH-2 regulates asymmetric cell division in the early C. elegans somatic gonad.
MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions.
Title: MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C27A2.6 (e-PCR)
- UniSTS:308644

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IC Inferred by Curator more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Wnt signaling pathway, regulating spindle positioning	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Wnt signaling pathway, regulating spindle positioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in left/right axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DiSHevelled related

NP_494937.4

Product from WormBase gene class dsh;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5078233..5081174 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062536.9 → NP_494937.4 LOW QUALITY PROTEIN: DiSHevelled related [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q18239

Conserved Domains (3) summary

smart00021
Location:101 → 184

DAX; Domain present in Dishevelled and axin

smart00228
Location:359 → 444

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd04438
Location:528 → 609

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...