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    ntl-3 NOT2/NOT3/NOT5 C-terminal domain-containing protein;Not3 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176614, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ntl-3
    Official Full Name
    NOT2/NOT3/NOT5 C-terminal domain-containing protein;Not3 domain-containing protein
    Primary source
    WormBase:WBGene00003826
    Locus tag
    CELE_Y56A3A.1
    See related
    AllianceGenome:WB:WBGene00003826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in body wall musculature. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ntl-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (11831012..11846465, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Fcf2 domain-containing protein Neighboring gene RNA-binding protein;RRM domain-containing protein Neighboring gene ncRNA Neighboring gene Membrane-bound transcription factor site-2 protease Neighboring gene L-dopachrome isomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans. Nousch M, et al. J Cell Sci, 2013 Sep 15. PMID 23843623
    2. A conserved PUF-Ago-eEF1A complex attenuates translation elongation. Friend K, et al. Nat Struct Mol Biol, 2012 Jan 8. PMID 22231398, Free PMC Article
    3. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Berends CW, et al. Mol Biol Cell, 2013 Jul. PMID 23699393, Free PMC Article
    4. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article
    5. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NOT2/NOT3/NOT5 C-terminal domain-containing protein;Not3 domain-containing protein
    NP_001076652.1
    • Confirmed by transcript evidence
    NP_001076653.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11831012..11846465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083183.4 → NP_001076652.1  Not3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFX8
      Conserved Domains (2) summary
      COG5665
      Location:12 → 700
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3 → 244
      Not3; Not1 N-terminal domain, CCR4-Not complex component

    2. NM_001083184.5 → NP_001076653.1  NOT2/NOT3/NOT5 C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0PDJ7
      Conserved Domains (1) summary
      COG5665
      Location:75 → 197
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    Nucleotide Protein
    Heading Accession and Version

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