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    mps-1 MiRP K channel accessory Subunit [ Caenorhabditis elegans ]

    Gene ID: 183012, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mps-1
    Official Full Name
    MiRP K channel accessory Subunit
    Primary source
    WormBase:WBGene00003403
    Locus tag
    CELE_C29F5.4
    See related
    AllianceGenome:WB:WBGene00003403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables potassium channel regulator activity and protein serine/threonine kinase activity. Involved in several processes, including hyperosmotic response; mechanosensory behavior; and negative regulation of potassium ion transport. Located in axolemma; dendrite membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is expressed in sensory neurons and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mps-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (6292452..6294361, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DUF4238 domain-containing protein Neighboring gene CN hydrolase domain-containing protein Neighboring gene RNase NYN domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution NMR of MPS-1 reveals a random coil cytosolic domain structure. Li P, et al. PLoS One, 2014. PMID 25347290, Free PMC Article
    2. Auto-phosphorylation of a voltage-gated K+ channel controls non-associative learning. Cai SQ, et al. EMBO J, 2009 Jun 3. PMID 19387491, Free PMC Article
    3. MPS-1 is a K+ channel beta-subunit and a serine/threonine kinase. Cai SQ, et al. Nat Neurosci, 2005 Nov. PMID 16222231
    4. A potassium channel-MiRP complex controls neurosensory function in Caenorhabditis elegans. Bianchi L, et al. J Biol Chem, 2003 Apr 4. PMID 12533541
    5. An evolutionarily conserved mode of modulation of Shaw-like K⁺ channels. Cotella D, et al. FASEB J, 2013 Apr. PMID 23233530, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic, biochemical and electrophysiological evidence show that KHT-1 and MPS-1 form a complex in vitro and in native mechanosensory PLM neurons, and that KHT-1 is a substrate for the kinase activity of MPS-1.
      Title: Auto-phosphorylation of a voltage-gated K+ channel controls non-associative learning.
    2. The transmembrane domain of MPS-1 is necessary and sufficient for MPS-1 complex formation; a hydropathic mechanism may allow MPS-1 to assemble with various voltage-gated potassium Kv channels, presumably modifying the electrical properties of each.
      Title: Molecular mechanisms underlying KVS-1-MPS-1 complex assembly.
    3. three different MPS subunits combine with KVS-1 to form both binary (MPS-1.KVS-1) and ternary (MPS-2.MPS-3.KVS-1) complexes in chemosensory neurons
      Title: A family of K+ channel ancillary subunits regulate taste sensitivity in Caenorhabditis elegans.
    4. This study report the K+ channel beta-subunit that is also a serine/threonine kinase. MPS-1 is a single-transmembrane domain protein that coassembles with voltage-gated K+ channel KVS-1 in the nervous system of the Caenorhabditis elegans.
      Title: MPS-1 is a K+ channel beta-subunit and a serine/threonine kinase.
    5. the cloning and functional characterization of a MiRP beta-subunit, MPS-1, and of a voltage-gated pore-forming potassium subunit, KVS-1 [MPS-1] [KVS-1]
      Title: A potassium channel-MiRP complex controls neurosensory function in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MiRP K channel accessory Subunit
    NP_495263.2
    • Product from WormBase gene class mps;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6292452..6294361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062862.5 → NP_495263.2  MiRP K channel accessory Subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495263.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q27GU3, Q86GJ0
    Nucleotide Protein
    Heading Accession and Version

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