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    F42A6.6 Hikeshi-like N-terminal domain-containing protein;Hikeshi-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 185650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F42A6.6
    Official Full Name
    Hikeshi-like N-terminal domain-containing protein;Hikeshi-like domain-containing protein
    Primary source
    WormBase:WBGene00018328
    Locus tag
    CELE_F42A6.6
    See related
    AllianceGenome:WB:WBGene00018328
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable Hsp70 protein binding activity and nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 13. Orthologous to human HIKESHI (heat shock protein nuclear import factor hikeshi). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F42A6.6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (3334042..3336873, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene BRCT domain-containing protein Neighboring gene ncRNA Neighboring gene Heterogeneous nuclear ribonucleoprotein A1 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Hikeshi-like N-terminal domain-containing protein;Hikeshi-like domain-containing protein
    NP_001263742.1
    • Confirmed by transcript evidence
    NP_001263743.1
    • Confirmed by transcript evidence
    NP_001263744.1
    • Confirmed by transcript evidence
    NP_001294457.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3334042..3336873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276815.3 → NP_001263744.1  Hikeshi-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8ERU5
      Conserved Domains (1) summary
      pfam05603
      Location:5 → 213
      DUF775; Protein of unknown function (DUF775)

    2. NM_001276813.3 → NP_001263742.1  Hikeshi-like N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263742.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L8E808
      Conserved Domains (1) summary
      pfam05603
      Location:5 → 150
      DUF775; Protein of unknown function (DUF775)

    3. NM_001307528.4 → NP_001294457.1  Hikeshi-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294457.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBW7
      Conserved Domains (1) summary
      pfam05603
      Location:5 → 197
      DUF775; Protein of unknown function (DUF775)

    4. NM_001276814.4 → NP_001263743.1  Hikeshi-like N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263743.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8FDZ3
      Conserved Domains (1) summary
      pfam05603
      Location:5 → 166
      DUF775; Protein of unknown function (DUF775)
    Nucleotide Protein
    Heading Accession and Version

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