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    larp-5 HTH La-type RNA-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171942, updated on 9-Dec-2024

    Summary

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    Official Symbol
    larp-5
    Official Full Name
    HTH La-type RNA-binding domain-containing protein
    Primary source
    WormBase:WBGene00004147
    Locus tag
    CELE_T12F5.5
    See related
    AllianceGenome:WB:WBGene00004147
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in positive regulation of translation. Predicted to be active in cytoplasmic stress granule and cytosol. Is expressed in neurons. Orthologous to human LARP4 (La ribonucleoprotein 4) and LARP4B (La ribonucleoprotein 4B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See larp-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (3732860..3740485, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative histone-lysine N-methyltransferase lin-59 Neighboring gene ATP-dependent RNA helicase glh-4 Neighboring gene RING-type domain-containing protein Neighboring gene Ribosome biogenesis protein NOP53 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis. Nykamp K, et al. RNA, 2008 Jul. PMID 18515547, Free PMC Article
    2. Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. Antonacci S, et al. G3 (Bethesda), 2015 Feb 10. PMID 25673135, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HTH La-type RNA-binding domain-containing protein
    NP_491209.3
    • Confirmed by transcript evidence
    NP_871824.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3732860..3740485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058808.5 → NP_491209.3  HTH La-type RNA-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491209.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44760
      Conserved Domains (2) summary
      cd08031
      Location:139 → 213
      LARP_4_5_like; La RNA-binding domain of proteins similar to La-related proteins 4 and 5
      cd12430
      Location:218 → 290
      RRM_LARP4_5_like; RNA recognition motif in La-related protein 4 (LARP4), La-related protein 5 (LARP5 or LARP4B) and similar proteins

    2. NM_182024.9 → NP_871824.3  HTH La-type RNA-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871824.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZU0
      Conserved Domains (2) summary
      cd08031
      Location:41 → 115
      LARP_4_5_like; La RNA-binding domain of proteins similar to La-related proteins 4 and 5
      cd12430
      Location:120 → 192
      RRM_LARP4_5_like; RNA recognition motif in La-related protein 4 (LARP4), La-related protein 5 (LARP5 or LARP4B) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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