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    lys-3 Lysozyme-like protein 3 [ Caenorhabditis elegans ]

    Gene ID: 179430, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lys-3
    Official Full Name
    Lysozyme-like protein 3
    Primary source
    WormBase:WBGene00003092
    Locus tag
    CELE_Y22F5A.6
    See related
    AllianceGenome:WB:WBGene00003092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in stress response to copper ion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lys-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (10282100..10283544, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Lysozyme-like protein 1 Neighboring gene Lysozyme-like protein 2 Neighboring gene CX domain-containing protein Neighboring gene Hexosyltransferase Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex. Hattori A, et al. PLoS Genet, 2013. PMID 23437011, Free PMC Article
    2. Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. Welker NC, et al. RNA, 2007 Jul. PMID 17526642, Free PMC Article
    3. Diversification and adaptive sequence evolution of Caenorhabditis lysozymes (Nematoda: Rhabditidae). Schulenburg H, et al. BMC Evol Biol, 2008 Apr 19. PMID 18423043, Free PMC Article
    4. Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress. Egge N, et al. Nat Commun, 2021 Mar 5. PMID 33674585, Free PMC Article
    5. Inducible antibacterial defense system in C. elegans. Mallo GV, et al. Curr Biol, 2002 Jul 23. PMID 12176330

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress response to copper ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in stress response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lysozyme-like protein 3
    NP_505644.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10282100..10283544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073243.4 → NP_505644.1  Lysozyme-like protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505644.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XXS1
      Conserved Domains (1) summary
      cd06416
      Location:65 → 267
      GH25_Lys1-like; Lys-1 is a lysozyme encoded by the Caenorhabditis elegans lys-1 gene. This gene is one of a several lysozyme genes upregulated upon infection by the Gram-negative bacterial pathogen Serratia marcescens. Lys-1 contains a glycosyl hydrolase family 25 ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XXS1.1

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