U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mec-1 BPTI/Kunitz inhibitor domain-containing protein;CRE-MEC-1 protein;Papilin [ Caenorhabditis elegans ]

    Gene ID: 188259, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mec-1
    Official Full Name
    BPTI/Kunitz inhibitor domain-containing protein;CRE-MEC-1 protein;Papilin
    Primary source
    WormBase:WBGene00003165
    Locus tag
    CELE_T07H8.4
    See related
    AllianceGenome:WB:WBGene00003165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in detection of mechanical stimulus involved in sensory perception of touch; extracellular structure organization; and mechanosensory behavior. Predicted to be active in extracellular space. Is expressed in PVT; cholinergic neurons; intestinal muscle; and touch receptor neurons. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mec-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    31
    Sequence:
    Chromosome: V; NC_003283.11 (6956537..6966425)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class gamma-31 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SSD domain-containing protein Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons. Emtage L, et al. Neuron, 2004 Dec 2. PMID 15572111
    2. Fibulin-1C and Fibulin-1D splice variants have distinct functions and assemble in a hemicentin-dependent manner. Muriel JM, et al. Development, 2005 Oct. PMID 16120639
    3. Touch-induced mechanical strain in somatosensory neurons is independent of extracellular matrix mutations in Caenorhabditis elegans. Nekimken AL, et al. Mol Biol Cell, 2020 Jul 21. PMID 32579427, Free PMC Article
    4. Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons. Pan CL, et al. Proc Natl Acad Sci U S A, 2011 May 31. PMID 21571636, Free PMC Article
    5. FIONA on Caenorhabditis elegans. Kural C, et al. Biochemistry, 2009 Jun 9. PMID 19397310, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in detection of mechanical stimulus involved in sensory perception of touch IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in extracellular structure organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mechanosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    BPTI/Kunitz inhibitor domain-containing protein;CRE-MEC-1 protein;Papilin
    NP_001024117.2
    • Confirmed by transcript evidence
    NP_001024118.1
    • Confirmed by transcript evidence
    NP_001024120.1
    • Partially confirmed by transcript evidence
    NP_001367615.1
    • Confirmed by transcript evidence
    NP_001367616.1
    • Confirmed by transcript evidence
    NP_001367617.1
    • Confirmed by transcript evidence
    NP_001367618.1
    • Confirmed by transcript evidence
    NP_001367619.1
    • Confirmed by transcript evidence
    NP_001379764.1
    • Confirmed by transcript evidence
    NP_741559.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6956537..6966425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171477.7 → NP_741559.3  Papilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741559.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5ZR42
      Conserved Domains (5) summary
      smart00131
      Location:1532 → 1584
      KU; BPTI/Kunitz family of serine protease inhibitors
      smart00179
      Location:202 → 240
      EGF_CA; Calcium-binding EGF-like domain
      cd00109
      Location:44 → 97
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:1739 → 1790
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      cl00101
      Location:265 → 304
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    2. NM_001028946.6 → NP_001024117.2  Papilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024117.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5ZR39
      Conserved Domains (5) summary
      smart00131
      Location:1520 → 1572
      KU; BPTI/Kunitz family of serine protease inhibitors
      smart00179
      Location:190 → 228
      EGF_CA; Calcium-binding EGF-like domain
      cd00109
      Location:44 → 97
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:1727 → 1778
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      cl00101
      Location:253 → 292
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    3. NM_001380680.1 → NP_001367617.1  Papilin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5ZR40
      Conserved Domains (5) summary
      smart00131
      Location:1531 → 1583
      KU; BPTI/Kunitz family of serine protease inhibitors
      smart00179
      Location:202 → 240
      EGF_CA; Calcium-binding EGF-like domain
      cd00109
      Location:44 → 97
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:1738 → 1789
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      cl00101
      Location:265 → 304
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    4. NM_001380681.1 → NP_001367615.1  CRE-MEC-1 protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5ZR41
      Conserved Domains (4) summary
      smart00131
      Location:1528 → 1580
      KU; BPTI/Kunitz family of serine protease inhibitors
      smart00179
      Location:198 → 236
      EGF_CA; Calcium-binding EGF-like domain
      cd00109
      Location:44 → 97
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cl00101
      Location:261 → 300
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    5. NM_001380682.1 → NP_001367616.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZ67
      Conserved Domains (4) summary
      smart00131
      Location:853 → 911
      KU; BPTI/Kunitz family of serine protease inhibitors
      smart00179
      Location:198 → 236
      EGF_CA; Calcium-binding EGF-like domain
      cd00109
      Location:44 → 97
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cl00101
      Location:261 → 300
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    6. NM_001380683.1 → NP_001367618.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5A8R1
      Conserved Domains (3) summary
      smart00179
      Location:198 → 236
      EGF_CA; Calcium-binding EGF-like domain
      cd00109
      Location:44 → 97
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cl00101
      Location:261 → 300
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    7. NM_001380684.1 → NP_001367619.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5A8R2
      Conserved Domains (2) summary
      smart00179
      Location:190 → 228
      EGF_CA; Calcium-binding EGF-like domain
      cd00109
      Location:44 → 97
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    8. NM_001392539.1 → NP_001379764.1  Papilin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5ZR36
      Conserved Domains (4) summary
      smart00131
      Location:1343 → 1395
      KU; BPTI/Kunitz family of serine protease inhibitors
      smart00179
      Location:13 → 51
      EGF_CA; Calcium-binding EGF-like domain
      pfam00014
      Location:1550 → 1601
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      cl00101
      Location:76 → 115
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    9. NM_001028947.3 → NP_001024118.1  CRE-MEC-1 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024118.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZ68
      Conserved Domains (4) summary
      smart00131
      Location:1479 → 1531
      KU; BPTI/Kunitz family of serine protease inhibitors
      smart00179
      Location:149 → 187
      EGF_CA; Calcium-binding EGF-like domain
      pfam00014
      Location:1686 → 1737
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      cl00101
      Location:212 → 251
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    10. NM_001028949.3 → NP_001024120.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024120.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5ZR35
      Conserved Domains (3) summary
      smart00131
      Location:1129 → 1181
      KU; BPTI/Kunitz family of serine protease inhibitors
      pfam00014
      Location:1336 → 1387
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      cl00101
      Location:935 → 976
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools