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    • Showing Current items.

    dgat-2 Acyltransferase [ Caenorhabditis elegans ]

    Gene ID: 180160, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dgat-2
    Official Full Name
    Acyltransferase
    Primary source
    WormBase:WBGene00010296
    Locus tag
    CELE_F59A1.10
    See related
    AllianceGenome:WB:WBGene00010296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable diacylglycerol O-acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Located in lipid droplet. Orthologous to several human genes including MOGAT1 (monoacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dgat-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (17660303..17661810)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene F-box domain-containing protein Neighboring gene tRNA Neighboring gene tRNA Neighboring gene Serpentine Receptor, class H;Serpentine Receptor, class T Neighboring gene tRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. S-Adenosyl methionine synthetase 1 limits fat storage in Caenorhabditis elegans. Ehmke M, et al. Genes Nutr, 2014 Mar. PMID 24510589, Free PMC Article
    2. The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface. Xu N, et al. J Cell Biol, 2012 Sep 3. PMID 22927462, Free PMC Article
    3. Early-life perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) exposure cause obesity by disrupting fatty acids metabolism and enhancing triglyceride synthesis in Caenorhabditis elegans. Lin TA, et al. Aquat Toxicol, 2022 Oct. PMID 36037606
    4. Neuronal control of lipid metabolism by STR-2 G protein-coupled receptor promotes longevity in Caenorhabditis elegans. Dixit A, et al. Aging Cell, 2020 Jun. PMID 32432390, Free PMC Article
    5. PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans. Wu J, et al. Nat Commun, 2018 Mar 22. PMID 29567958, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Acyltransferase
    NP_507469.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      17660303..17661810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075068.5 → NP_507469.1  Acyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507469.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUW0
      Conserved Domains (1) summary
      pfam03982
      Location:50 → 345
      DAGAT; Diacylglycerol acyltransferase
    Nucleotide Protein
    Heading Accession and Version

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