ift-81 IFT81 calponin homology domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ift-81
Official Full Name: IFT81 calponin homology domain-containing protein
Primary source: WormBase:WBGene00017973
Locus tag: CELE_F32A6.2
See related: AllianceGenome:WB:WBGene00017973
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables microtubule binding activity. Involved in chemotaxis; detection of stimulus involved in sensory perception; and intraciliary transport. Located in non-motile cilium. Is expressed in nervous system. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 19 with or without polydactyly. Orthologous to human IFT81 (intraflagellar transport 81). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ift-81 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 19

Sequence:: Chromosome: X; NC_003284.9 (5298561..5306542)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F32A6.1 (e-PCR)
- UniSTS:316691

F32A6.2 (e-PCR)
- UniSTS:322094

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in detection of stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intraciliary transport	IEA Inferred from Electronic Annotation more info
involved_in intraciliary transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IEA Inferred from Electronic Annotation more info
part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle B	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: IFT81 calponin homology domain-containing protein

NP_508900.6

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5298561..5306542

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076499.9 → NP_508900.6 IFT81 calponin homology domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508900.6

Status: REVIEWED

UniProtKB/TrEMBL

A8DYR7

Conserved Domains (2) summary

TIGR02168
Location:137 → 384

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam18383
Location:8 → 127

IFT81_CH; Intraflagellar transport 81 calponin homology domain