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    xpo-3 Exportin-T [ Caenorhabditis elegans ]

    Gene ID: 177581, updated on 9-Dec-2024

    Summary

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    Official Symbol
    xpo-3
    Official Full Name
    Exportin-T
    Primary source
    WormBase:WBGene00002080
    Locus tag
    CELE_C49H3.10
    See related
    AllianceGenome:WB:WBGene00002080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tRNA binding activity. Predicted to be involved in tRNA re-export from nucleus. Predicted to be located in nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm and nuclear matrix. Is expressed in intestine and nervous system. Orthologous to human XPOT (exportin for tRNA). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See xpo-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (7916689..7924032, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cortactin-binding protein-2 N-terminal domain-containing protein Neighboring gene C3HC-type domain-containing protein Neighboring gene CCR4-NOT transcription complex subunit 4 Neighboring gene Sm domain-containing protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene ncRNA Neighboring gene UPF0642 protein YBL028C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins. Quan Y, et al. Mol Cell Proteomics, 2008 Jul. PMID 18353765, Free PMC Article
    2. Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation. Itani OA, et al. Curr Biol, 2021 Jan 11. PMID 33157031, Free PMC Article
    3. Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Askjaer P, et al. Mol Biol Cell, 2002 Dec. PMID 12475958, Free PMC Article
    4. A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response. Held JP, et al. Elife, 2022 Apr 22. PMID 35451962, Free PMC Article
    5. AKIR-1 regulates proteasome subcellular function in Caenorhabditis elegans. Pispa J, et al. iScience, 2023 Oct 20. PMID 37767001, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in macromolecule localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitrogen compound transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in tRNA re-export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA re-export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nuclear matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Exportin-T
    NP_001294153.1
    • Partially confirmed by transcript evidence
    NP_001368437.1
    • Confirmed by transcript evidence
    NP_501320.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7916689..7924032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068919.8 → NP_501320.2  Exportin-T [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501320.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GYQ7
      Conserved Domains (1) summary
      pfam08389
      Location:98 → 244
      Xpo1; Exportin 1-like protein

    2. NM_001307224.3 → NP_001294153.1  Exportin-T [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RQY2
      Conserved Domains (1) summary
      pfam08389
      Location:98 → 246
      Xpo1; Exportin 1-like protein

    3. NM_001380346.1 → NP_001368437.1  Exportin-T [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RY26
    Nucleotide Protein
    Heading Accession and Version

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