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    lgl-1 Lethal giant larvae homologue 2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180435, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lgl-1
    Official Full Name
    Lethal giant larvae homologue 2 domain-containing protein
    Primary source
    WormBase:WBGene00018987
    Locus tag
    CELE_F56F10.4
    See related
    AllianceGenome:WB:WBGene00018987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in establishment of spindle orientation and protein localization. Located in basolateral plasma membrane and cell cortex. Is expressed in epithelial cell; intestine; and spermathecal cell. Orthologous to human LLGL1 (LLGL scribble cell polarity complex component 1) and LLGL2 (LLGL scribble cell polarity complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lgl-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (864097..871089, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cysteine dioxygenase 1 Neighboring gene ncRNA Neighboring gene tRNA-Tyr Neighboring gene Putative serine protease F56F10.1 Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Role of pkc-3 and Genetic Suppressors in Caenorhabditis elegans Epithelial Cell Junction Formation. Montoyo-Rosario JG, et al. Genetics, 2020 Apr. PMID 32005655, Free PMC Article
    2. LGL can partition the cortex of one-cell Caenorhabditis elegans embryos into two domains. Hoege C, et al. Curr Biol, 2010 Jul 27. PMID 20579886
    3. In vitro Reconstitution of a Membrane Switch Mechanism for the Polarity Protein LGL. Visco I, et al. J Mol Biol, 2016 Dec 4. PMID 27720986
    4. The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo. Beatty A, et al. Development, 2010 Dec. PMID 21041363, Free PMC Article
    5. SAIBR: a simple, platform-independent method for spectral autofluorescence correction. Rodrigues NTL, et al. Development, 2022 Jul 15. PMID 35713287, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upon membrane binding, LGL-1 membrane binding sequence folds into an alpha-helix in which three regions can be identified: a positively charged patch, a switch area containing the three atypical protein kinase C phosphorylation sites, and a hydrophobic area probably buried in the membrane.
      Title: In vitro Reconstitution of a Membrane Switch Mechanism for the Polarity Protein LGL.
    2. LGL can partition the cortex of one-cell Caenorhabditis elegans embryos into two domains.
      Title: LGL can partition the cortex of one-cell Caenorhabditis elegans embryos into two domains.
    3. Overexpression of LGL-1 is sufficient to rescue loss of PAR-2 function.
      Title: The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.
    4. LGL-1 and PAR-2 affect cortical myosin distribution.
      Title: PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Lethal giant larvae homologue 2 domain-containing protein
    NP_508169.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      864097..871089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075768.6 → NP_508169.2  Lethal giant larvae homologue 2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508169.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEI1
      Conserved Domains (1) summary
      pfam08366
      Location:273 → 364
      LLGL; LLGL2
    Nucleotide Protein
    Heading Accession and Version

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