U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    grwd-1 Glutamate-rich WD repeat-containing protein 1 [ Caenorhabditis elegans ]

    Gene ID: 175701, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    grwd-1
    Official Full Name
    Glutamate-rich WD repeat-containing protein 1
    Primary source
    WormBase:WBGene00021899
    Locus tag
    CELE_Y54H5A.1
    See related
    AllianceGenome:WB:WBGene00021899
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in ribosome biogenesis. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human GRWD1 (glutamate rich WD repeat containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See grwd-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5153543..5155436)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein HGH1 homolog Neighboring gene ncRNA Neighboring gene RNA-binding protein 42 Neighboring gene putative cytosolic Fe-S cluster assembly factor oxy-4 Neighboring gene pseudo Neighboring gene Trafficking protein particle complex subunit 2-like protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ribosome biogenesis disruption mediated chromatin structure changes revealed by SRAtac, a customizable end to end analysis pipeline for ATAC-seq. Freeman TF, et al. BMC Genomics, 2023 Sep 1. PMID 37658321, Free PMC Article
    2. [FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode. Fujii M, et al. Genes Cells, 2009 Apr. PMID 19335616
    3. Inhibition of ribosome biogenesis in the epidermis is sufficient to trigger organism-wide growth quiescence independently of nutritional status in C. elegans. Zhao Q, et al. PLoS Biol, 2023 Aug. PMID 37651423, Free PMC Article
    4. Gamma radiation induces life stage-dependent reprotoxicity in Caenorhabditis elegans via impairment of spermatogenesis. Maremonti E, et al. Sci Total Environ, 2019 Dec 10. PMID 31425988
    5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Glutamate-rich WD repeat-containing protein 1
    NP_498091.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5153543..5155436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065690.8 → NP_498091.1  Glutamate-rich WD repeat-containing protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498091.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N393
      Conserved Domains (3) summary
      sd00039
      Location:232 → 273
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:54 → 122
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:182 → 401
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools