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    nlp-40 Peptide P4 [ Caenorhabditis elegans ]

    Gene ID: 171591, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nlp-40
    Official Full Name
    Peptide P4
    Primary source
    WormBase:WBGene00022276
    Locus tag
    CELE_Y74C9A.2
    See related
    AllianceGenome:WB:WBGene00022276
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable neuropeptide receptor binding activity. Involved in neuropeptide signaling pathway and positive regulation of defecation. Located in extracellular space. Is expressed in coelomocyte and intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nlp-40 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (11495..16837)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Alpha N-terminal protein methyltransferase 1 Neighboring gene REST corepressor rcor-1 Neighboring gene pseudo Neighboring gene Sestrin homolog Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuropeptide signaling regulates the susceptibility of developing C. elegans to anoxia. Doshi S, et al. Free Radic Biol Med, 2019 Feb 1. PMID 30529384
    2. Neuropeptide secreted from a pacemaker activates neurons to control a rhythmic behavior. Wang H, et al. Curr Biol, 2013 May 6. PMID 23583549, Free PMC Article
    3. A leak K(+) channel TWK-40 sustains the rhythmic motor program. Yue Z, et al. PNAS Nexus, 2024 Jul. PMID 38957449, Free PMC Article
    4. rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans. Lin-Moore AT, et al. PLoS Genet, 2021 Nov. PMID 34818334, Free PMC Article
    5. Neuropeptide signaling: from the gut. Zhao B, et al. Curr Biol, 2013 Jun 3. PMID 23743414

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables neuropeptide receptor binding IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Peptide P4
    NP_001293206.1
    • Confirmed by transcript evidence
    NP_490661.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11495..16837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058259.5 → NP_490661.1  Peptide P4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490661.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N4D8, V6CJ31

    2. NM_001306277.3 → NP_001293206.1  Peptide P4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N4D8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N4D8.1

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