top-3B DNA topoisomerase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: top-3B
Official Full Name: DNA topoisomerase
Primary source: WormBase:WBGene00012995
Locus tag: CELE_Y48C3A.14
See related: AllianceGenome:WB:WBGene00012995
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA recombination; DNA repair; and DNA topological change. Predicted to be active in nucleus. Is expressed in head and intestine. Orthologous to human TOP3B (DNA topoisomerase III beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See top-3B in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (13389761..13402016)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y48C3A.r (e-PCR)
- UniSTS:324366

Y48C3A.q (e-PCR)
- UniSTS:323700

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase activity	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA topological change	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA topological change	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA topoisomerase

NP_001254381.1

Confirmed by transcript evidence

NP_001368106.1

Confirmed by transcript evidence

NP_001368107.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

13389761..13402016

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267452.3 → NP_001254381.1 DNA topoisomerase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254381.1

Status: REVIEWED

UniProtKB/TrEMBL

H1UBJ9

Conserved Domains (3) summary

cd03362
Location:4 → 168

TOPRIM_TopoIA_TopoIII; TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving ...

PRK07219
Location:4 → 739

PRK07219; DNA topoisomerase I; Validated

cd00186
Location:174 → 593

TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
NM_001381639.1 → NP_001368106.1 DNA topoisomerase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H1UBJ6

Conserved Domains (1) summary

pfam01131
Location:34 → 448

Topoisom_bac; DNA topoisomerase
NM_001381640.1 → NP_001368107.1 DNA topoisomerase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H1UBJ8

Conserved Domains (2) summary

PRK07219
Location:1 → 234

PRK07219; DNA topoisomerase I; Validated

cl30544
Location:1 → 88

TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...