pvf-1 Platelet-derived growth factor (PDGF) family profile domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: pvf-1
Official Full Name: Platelet-derived growth factor (PDGF) family profile domain-containing protein
Primary source: WormBase:WBGene00004249
Locus tag: CELE_Y39A3CL.6
See related: AllianceGenome:WB:WBGene00004249
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable growth factor receptor binding activity. Involved in negative regulation of netrin-activated signaling pathway and nematode male tail tip morphogenesis. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in body wall musculature. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and high grade glioma (multiple). Orthologous to human PDGFA (platelet derived growth factor subunit A) and PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

VER/VEGF receptors regulate AMPA receptor surface levels and glutamatergic behavior.
Title: VER/VEGF receptors regulate AMPA receptor surface levels and glutamatergic behavior.
C. elegans PVF-1 inhibits permissive UNC-40 signalling through CED-10 GTPase to position the male ray 1 sensillum.
Title: C. elegans PVF-1 inhibits permissive UNC-40 signalling through CED-10 GTPase to position the male ray 1 sensillum.
The identification and characterization of PVF-1 from C. elegans is reported.
Title: The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis.

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Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of netrin-activated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode male tail tip morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

Preferred Names: Platelet-derived growth factor (PDGF) family profile domain-containing protein

NP_497461.1

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The following sections contain reference sequences that belong to a specific genome build. Explain