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    exl-1 Chloride intracellular channel exl-1 [ Caenorhabditis elegans ]

    Gene ID: 175100, updated on 9-Dec-2024

    Summary

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    Official Symbol
    exl-1
    Official Full Name
    Chloride intracellular channel exl-1
    Primary source
    WormBase:WBGene00001371
    Locus tag
    CELE_F26H11.5
    See related
    AllianceGenome:WB:WBGene00001371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Located in several cellular components, including bounding membrane of organelle; muscle cell projection membrane; and striated muscle dense body. Is expressed in coelomocyte; intestine; muscle cell; and neurons. Used to study alcohol use disorder. Orthologous to several human genes including CLIC2 (chloride intracellular channel 2) and CLIC4 (chloride intracellular channel 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See exl-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (14412202..14413475, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Bromo domain-containing protein;Bromodomain-containing protein;DDT domain-containing protein;Nucleosome-remodeling factor subunit NURF301;Nucleosome-remodeling factor subunit NURF301-like Neighboring gene ncRNA Neighboring gene ULP_PROTEASE domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Double-Strand Break factor Neighboring gene Plexin-2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans. Liang J, et al. J Vis Exp, 2018 Jul 30. PMID 30102267, Free PMC Article
    2. Chloride intracellular channel proteins respond to heat stress in Caenorhabditis elegans. Liang J, et al. PLoS One, 2017. PMID 28886120, Free PMC Article
    3. Mapping functional domains of chloride intracellular channel (CLIC) proteins in vivo. Berry KL, et al. J Mol Biol, 2006 Jun 23. PMID 16737711
    4. A C. elegans CLIC-like protein required for intracellular tube formation and maintenance. Berry KL, et al. Science, 2003 Dec 19. PMID 14684823
    5. Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice. Bhandari P, et al. Genes Brain Behav, 2012 Jun. PMID 22239914, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in muscle cell projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Chloride intracellular channel exl-1
    NP_497000.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14412202..14413475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064599.5 → NP_497000.1  Chloride intracellular channel exl-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497000.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45405
      Conserved Domains (2) summary
      TIGR00862
      Location:2 → 213
      O-ClC; intracellular chloride channel protein
      cl02776
      Location:98 → 210
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45405.2

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