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    hal-2 Coiled-coil domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3564857, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hal-2
    Official Full Name
    Coiled-coil domain-containing protein
    Primary source
    WormBase:WBGene00011819
    Locus tag
    CELE_T16H12.11
    See related
    AllianceGenome:WB:WBGene00011819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in nucleoplasm. Is expressed in germ cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hal-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (10087188..10088931, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene General transcription factor IIH subunit 2 Neighboring gene Speckle-type POZ protein homolog Neighboring gene Kelch repeat-containing protein kel-10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HAL-2 promotes homologous pairing during Caenorhabditis elegans meiosis by antagonizing inhibitory effects of synaptonemal complex precursors. Zhang W, et al. PLoS Genet, 2012. PMID 22912597, Free PMC Article
    2. Automated and customizable quantitative image analysis of whole Caenorhabditis elegans germlines. Toraason E, et al. Genetics, 2021 Mar 31. PMID 33772283, Free PMC Article
    3. Spatial Regulation of Polo-Like Kinase Activity During Caenorhabditis elegans Meiosis by the Nucleoplasmic HAL-2/HAL-3 Complex. Roelens B, et al. Genetics, 2019 Sep. PMID 31345995, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hal-2 mutants exhibit multiple meiotic prophase defects. HAL-2/HAL-3 protein complex regulates localization and activity of meiotic Polo-like kinases.
      Title: Spatial Regulation of Polo-Like Kinase Activity During Caenorhabditis elegans Meiosis by the Nucleoplasmic HAL-2/HAL-3 Complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Coiled-coil domain-containing protein
    NP_001379406.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10087188..10088931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392184.1 → NP_001379406.1  Coiled-coil domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YWU3
    Nucleotide Protein
    Heading Accession and Version

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