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    F55F8.3 Periodic tryptophan protein 2 homolog [ Caenorhabditis elegans ]

    Gene ID: 172224, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F55F8.3
    Official Full Name
    Periodic tryptophan protein 2 homolog
    Primary source
    WormBase:WBGene00018891
    Locus tag
    CELE_F55F8.3
    See related
    AllianceGenome:WB:WBGene00018891
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit assembly. Predicted to be located in nucleolus. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Orthologous to human PWP2 (PWP2 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F55F8.3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (5649756..5653648, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein-tyrosine phosphatase catalytic domain-containing protein Neighboring gene Col_cuticle_N domain-containing protein Neighboring gene ATP-dependent RNA helicase Neighboring gene CBF1-interacting co-repressor CIR N-terminal domain-containing protein Neighboring gene Ribosome biogenesis protein WDR12 homolog Neighboring gene Mitochondrial fission factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Pwp2p-containing subcomplex of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Periodic tryptophan protein 2 homolog
    NP_491653.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5649756..5653648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059252.6 → NP_491653.2  Periodic tryptophan protein 2 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491653.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91341
      Conserved Domains (4) summary
      COG2319
      Location:248 → 618
      WD40; WD40 repeat [General function prediction only]
      pfam04003
      Location:760 → 861
      Utp12; Dip2/Utp12 Family
      sd00039
      Location:318 → 358
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:321 → 608
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91341.2

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