U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    smg-5 PIN domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172391, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    smg-5
    Official Full Name
    PIN domain-containing protein
    Primary source
    WormBase:WBGene00004883
    Locus tag
    CELE_W02D3.8
    See related
    AllianceGenome:WB:WBGene00004883
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DEAD/H-box RNA helicase binding activity and protein phosphatase 2A binding activity. Involved in embryonic genitalia morphogenesis and negative regulation of gene expression. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See smg-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (6734028..6736161, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ADP/ATP translocase Neighboring gene Fatty acid-binding protein homolog 5 Neighboring gene Dihydroorotate dehydrogenase (quinone), mitochondrial Neighboring gene Cytochrome b5 heme-binding domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Stop making nonSense: the C. elegans smg genes. Mango SE. Trends Genet, 2001 Nov. PMID 11672865
    2. An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Jonas S, et al. Genes Dev, 2013 Jan 15. PMID 23348841, Free PMC Article
    3. SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans. Grimson A, et al. Mol Cell Biol, 2004 Sep. PMID 15314158, Free PMC Article
    4. Functional analysis of an intron 3' splice site in Caenorhabditis elegans. Zhang H, et al. RNA, 1996 Apr. PMID 8634918, Free PMC Article
    5. smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans. Morrison M, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275202, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that the role of SMG-5 is to direct protein phosphatase 2A to its SMG-2 substrate
      Title: SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DEAD/H-box RNA helicase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA nuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 2A binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    PIN domain-containing protein
    NP_491929.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6734028..6736161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059528.9 → NP_491929.1  PIN domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491929.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECF1
      Conserved Domains (1) summary
      smart00670
      Location:427 → 525
      PINc; Large family of predicted nucleotide-binding domains
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools