chd-7 Chromodomain and Helicase Domain protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: chd-7
Official Full Name: Chromodomain and Helicase Domain protein
Primary source: WormBase:WBGene00007053
Locus tag: CELE_T04D1.4
See related: AllianceGenome:WB:WBGene00007053
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and histone binding activity. Predicted to be involved in chromatin remodeling and regulation of gene expression. Predicted to be located in chromatin. Predicted to be active in nucleus. Used to study CHARGE syndrome. Human ortholog(s) of this gene implicated in CHARGE syndrome and hypogonadotropic hypogonadism 5 with or without anosmia. Orthologous to several human genes including CHD6 (chromodomain helicase DNA binding protein 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See chd-7 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (4685865..4698575, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The CHARGE syndrome ortholog CHD-7 regulates TGF-beta pathways in Caenorhabditis elegans.
Title: The CHARGE syndrome ortholog CHD-7 regulates TGF-β pathways in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T04D1.4 (e-PCR)
- UniSTS:310653

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent chromatin remodeler activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Chromodomain and Helicase Domain protein

NP_491426.2

Product from WormBase gene class chd;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4685865..4698575 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059025.8 → NP_491426.2 Chromodomain and Helicase Domain protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491426.2

Status: REVIEWED

UniProtKB/TrEMBL

G4RQM3, O61845

Conserved Domains (8) summary

smart00592
Location:2672 → 2716

BRK; domain in transcription and CHROMO domain helicases

smart00717
Location:2073 → 2133

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

smart00298
Location:1059 → 1095

CHROMO; Chromatin organization modifier domain

cd00046
Location:1216 → 1369

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

cd00167
Location:2075 → 2126

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00176
Location:1200 → 1488

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1520 → 1635

Helicase_C; Helicase conserved C-terminal domain

pfam00385
Location:1115 → 1163

Chromo; Chromo (CHRromatin Organization MOdifier) domain