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    ltah-1.2 Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177123, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ltah-1.2
    Official Full Name
    Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00022610
    Locus tag
    CELE_ZC416.6
    See related
    AllianceGenome:WB:WBGene00022610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aminopeptidase activity and epoxide hydrolase activity. Involved in negative regulation of fatty acid transport; regulation of lipid storage; and regulation of peptide transport. Predicted to be active in cytosol. Is expressed in intestine. Orthologous to human LTA4H (leukotriene A4 hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ltah-1.2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (3609218..3613072, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene BRCT domain-containing protein Neighboring gene Stress-activated protein kinase JNK Neighboring gene Choline O-acetyltransferase Neighboring gene Vesicular acetylcholine transporter unc-17 Neighboring gene Cysteine-rich transmembrane CYSTM domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The complement of family M1 aminopeptidases of Haemonchus contortus--Biotechnological implications. Mohandas N, et al. Biotechnol Adv, 2016 Mar-Apr. PMID 26597954
    2. MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans. Sendoel A, et al. Cell Death Differ, 2019 Oct. PMID 30728462, Free PMC Article
    3. A glutathione peroxidase, intracellular peptidases and the TOR complexes regulate peptide transporter PEPT-1 in C. elegans. Benner J, et al. PLoS One, 2011. PMID 21980510, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables epoxide hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of fatty acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of peptide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein
    NP_001368204.1
    • Confirmed by transcript evidence
    NP_500385.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3609218..3613072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067984.7 → NP_500385.1  Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500385.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44183
      Conserved Domains (2) summary
      cd09599
      Location:12 → 455
      M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
      pfam09127
      Location:500 → 614
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    2. NM_001380155.1 → NP_001368204.1  Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PAP4
      Conserved Domains (2) summary
      cd09599
      Location:1 → 364
      M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
      pfam09127
      Location:409 → 523
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    Nucleotide Protein
    Heading Accession and Version

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