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    ins-7 Insulin-like peptide 7;putative insulin-like peptide beta-type 4 [ Caenorhabditis elegans ]

    Gene ID: 191688, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ins-7
    Official Full Name
    Insulin-like peptide 7;putative insulin-like peptide beta-type 4
    Primary source
    WormBase:WBGene00002090
    Locus tag
    CELE_ZK1251.2
    See related
    AllianceGenome:WB:WBGene00002090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hormone activity. Involved in olfactory learning. Predicted to be located in extracellular region and membrane. Is expressed in several structures, including distal tip cell; egg-laying apparatus; head muscle; neurons; and somatic nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ins-7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (9682011..9682845, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene INSulin related Neighboring gene ncRNA Neighboring gene Histone H2A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling. Kawli T, et al. Nat Immunol, 2008 Dec. PMID 18854822
    2. Disruption of ins-11, a Caenorhabditis elegans insulin-like gene, and phenotypic analyses of the gene-disrupted animal. Kawano T, et al. Biosci Biotechnol Biochem, 2006 Dec. PMID 17151440
    3. ins-7 Gene expression is partially regulated by the DAF-16/IIS signaling pathway in Caenorhabditis elegans under celecoxib intervention. Zheng S, et al. PLoS One, 2014. PMID 24945567, Free PMC Article
    4. Diapause is associated with a change in the polarity of secretion of insulin-like peptides. Matsunaga Y, et al. Nat Commun, 2016 Feb 3. PMID 26838180, Free PMC Article
    5. Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. Honjoh S, et al. Nature, 2009 Feb 5. PMID 19079239

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that, under high glucose conditions, mitochondria-mediated oxidative stress and glycation are downstream targets of ins-7; this impairs neuronal system function and longevity via non-neuronal/neuronal crosstalk by affecting sod-3 and glod-4. (ins-7 = insulin related Probable insulin-like peptide beta-type 4; sod-3 = mitochondrial Mn+2 superoxide dismutase; glod-4 = glyoxalase 1)
      Title: Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.
    2. the expression of ins-7, a DAF-16 target gene, was abnormally regulated by celecoxib.
      Title: ins-7 Gene expression is partially regulated by the DAF-16/IIS signaling pathway in Caenorhabditis elegans under celecoxib intervention.
    3. INS-7 secreted from the nervous system functioned in a non-cell autonomous way to activate the insulin pathway and alter basal and inducible expression of immunity-related genes
      Title: Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling.
    4. DAF-16 regulates ins-7 expression in the intestine. Preventing this regulation blocks FOXO-to-FOXO signaling from the intestine to other tissues.
      Title: Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in olfactory learning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Insulin-like peptide 7;putative insulin-like peptide beta-type 4
    NP_001255417.1
    • Confirmed by transcript evidence
    NP_001255418.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9682011..9682845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268489.3 → NP_001255418.1  Insulin-like peptide 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255418.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23430
      Conserved Domains (1) summary
      pfam03488
      Location:58 → 105
      Ins_beta; Nematode insulin-related peptide beta type

    2. NM_001268488.3 → NP_001255417.1  putative insulin-like peptide beta-type 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255417.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2S9
      Conserved Domains (1) summary
      pfam03488
      Location:69 → 116
      Ins_beta; Nematode insulin-related peptide beta type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23430.1

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