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    scav-3 Sensory neuron membrane protein 2 [ Caenorhabditis elegans ]

    Gene ID: 176673, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scav-3
    Official Full Name
    Sensory neuron membrane protein 2
    Primary source
    WormBase:WBGene00013039
    Locus tag
    CELE_Y49E10.20
    See related
    AllianceGenome:WB:WBGene00013039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable scavenger receptor activity. Predicted to be active in membrane. Is expressed in several structures, including excretory cell; intestine; nervous system; reproductive system; and tail. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; progressive myoclonus epilepsy 4; and pulmonary tuberculosis. Orthologous to several human genes including SCARB1 (scavenger receptor class B member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See scav-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (12453588..12456850, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene Anillin-like protein 1 Neighboring gene Conserved oligomeric Golgi complex subunit 7;RAD50-interacting protein 1 Neighboring gene Phosphoryl Seryl-TRNA (Ser/Sec) Kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity. Li Y, et al. J Cell Biol, 2016 Oct 24. PMID 27810910, Free PMC Article
    2. Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging. Ogura M, et al. EMBO Rep, 2023 Dec 6. PMID 37987447, Free PMC Article
    3. Experimental considerations for study of C. elegans lysosomal proteins. Clancy JC, et al. G3 (Bethesda), 2023 Apr 11. PMID 36748711, Free PMC Article
    4. Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton. Shi L, et al. J Cell Biol, 2022 Jul 4. PMID 35575797, Free PMC Article
    5. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. Means TK, et al. J Exp Med, 2009 Mar 16. PMID 19237602, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCAV-3 affects apoptotic cell degradation in Caenorhabditis elegans.
      Title: SCAV-3 affects apoptotic cell degradation in Caenorhabditis elegans.
    2. SCAV-3 is essential for preserving lysosomal membrane stability and that modulation of lysosome integrity by the insulin/IGF-1 signaling pathway affects longevity.
      Title: The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables scavenger receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sensory neuron membrane protein 2
    NP_499625.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12453588..12456850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067224.8 → NP_499625.2  Sensory neuron membrane protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499625.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XTT3
      Conserved Domains (1) summary
      pfam01130
      Location:52 → 499
      CD36; CD36 family
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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