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    F19B6.1 Uridine kinase;Uridine-cytidine kinase 1-like 1 [ Caenorhabditis elegans ]

    Gene ID: 178181, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F19B6.1
    Official Full Name
    Uridine kinase;Uridine-cytidine kinase 1-like 1
    Primary source
    WormBase:WBGene00008948
    Locus tag
    CELE_F19B6.1
    See related
    AllianceGenome:WB:WBGene00008948
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; cytidine kinase activity; and uridine kinase activity. Involved in embryo development. Predicted to be active in cytoplasm. Is expressed in body wall musculature; hypodermis; pharynx; and reproductive system. Orthologous to human UCKL1 (uridine-cytidine kinase 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F19B6.1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (12330985..12336041, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene FLYWCH-type domain-containing protein Neighboring gene Ubiquitin fusion degradation protein 1 homolog Neighboring gene Uncharacterized protein Neighboring gene ABC transporter domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RAD-6: pyrimidine synthesis and radiation sensitivity in Caenorhabditis elegans. Merry A, et al. Biochem J, 2014 Mar 1. PMID 24262006
    2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Uridine kinase;Uridine-cytidine kinase 1-like 1
    NP_001255641.1
    • Confirmed by transcript evidence
    NP_001368094.1
    • Confirmed by transcript evidence
    NP_001379111.1
    • Confirmed by transcript evidence
    NP_502350.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12330985..12336041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392413.1 → NP_001379111.1  Uridine kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19583
      Conserved Domains (2) summary
      cd02023
      Location:66 → 265
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:301 → 503
      UPRTase; Uracil phosphoribosyltransferase

    2. NM_001380483.1 → NP_001368094.1  Uridine kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2A8
      Conserved Domains (2) summary
      cd02023
      Location:120 → 319
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:355 → 557
      UPRTase; Uracil phosphoribosyltransferase

    3. NM_069949.5 → NP_502350.1  Uridine kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502350.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3I7
      Conserved Domains (3) summary
      COG0572
      Location:99 → 299
      Udk; Uridine kinase [Nucleotide transport and metabolism]
      cd02023
      Location:106 → 305
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:341 → 543
      UPRTase; Uracil phosphoribosyltransferase

    4. NM_001268712.3 → NP_001255641.1  Uridine-cytidine kinase 1-like 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT38
      Conserved Domains (1) summary
      pfam14681
      Location:1 → 133
      UPRTase; Uracil phosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version

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