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    ZC434.9 ShKT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZC434.9
    Official Full Name
    ShKT domain-containing protein
    Primary source
    WormBase:WBGene00013895
    Locus tag
    CELE_ZC434.9
    See related
    AllianceGenome:WB:WBGene00013895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZC434.9 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    16
    Sequence:
    Chromosome: I; NC_003279.8 (10356251..10360898)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene glutamate--tRNA ligase Neighboring gene Nicastrin Neighboring gene Cytochrome c oxidase assembly factor 6 homolog;PRORP domain-containing protein Neighboring gene putative arginine kinase ZC434.8 Neighboring gene Specificity protein transcription factor 1 Neighboring gene Ubiquitin-like protein NEDD8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ShKT domain-containing protein
    NP_001021851.2
    • Confirmed by transcript evidence
    NP_001021852.2
    • Confirmed by transcript evidence
    NP_001251356.1
    • Confirmed by transcript evidence
    NP_001251357.1
    • Confirmed by transcript evidence
    NP_001251358.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10356251..10360898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026681.4 → NP_001021852.2  ShKT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021852.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JLE3
      Conserved Domains (3) summary
      cd03860
      Location:141 → 454
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
      pfam01549
      Location:486 → 523
      ShK; ShK domain-like
      pfam02244
      Location:45 → 111
      Propep_M14; Carboxypeptidase activation peptide

    2. NM_001264428.4 → NP_001251357.1  ShKT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251357.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MU28
      Conserved Domains (3) summary
      cd03860
      Location:141 → 454
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
      pfam01549
      Location:586 → 623
      ShK; ShK domain-like
      pfam02244
      Location:45 → 111
      Propep_M14; Carboxypeptidase activation peptide

    3. NM_001026680.7 → NP_001021851.2  ShKT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021851.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23318
      Conserved Domains (3) summary
      cd03860
      Location:141 → 454
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
      pfam01549
      Location:535 → 572
      ShK; ShK domain-like
      pfam02244
      Location:45 → 111
      Propep_M14; Carboxypeptidase activation peptide

    4. NM_001264427.2 → NP_001251356.1  ShKT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MU29
      Conserved Domains (3) summary
      cd03860
      Location:141 → 454
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
      pfam01549
      Location:682 → 719
      ShK; ShK domain-like
      pfam02244
      Location:45 → 111
      Propep_M14; Carboxypeptidase activation peptide

    5. NM_001264429.3 → NP_001251358.1  ShKT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251358.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MU30
      Conserved Domains (3) summary
      cd03860
      Location:141 → 454
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
      pfam01549
      Location:537 → 574
      ShK; ShK domain-like
      pfam02244
      Location:45 → 111
      Propep_M14; Carboxypeptidase activation peptide
    Nucleotide Protein
    Heading Accession and Version

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