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    cyp-33C2 CYtochrome P450 family [ Caenorhabditis elegans ]

    Gene ID: 178695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyp-33C2
    Official Full Name
    CYtochrome P450 family
    Primary source
    WormBase:WBGene00016697
    Locus tag
    CELE_C45H4.17
    See related
    AllianceGenome:WB:WBGene00016697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); carcinoma (multiple); drug dependence (multiple); and hematologic cancer (multiple). Orthologous to several human genes including CYP2A7 (cytochrome P450 family 2 subfamily A member 7); CYP2B6 (cytochrome P450 family 2 subfamily B member 6); and CYP2C18 (cytochrome P450 family 2 subfamily C member 18). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyp-33C2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (2183488..2186599)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CYtochrome P450 family Neighboring gene Serpentine Receptor, class BC (Class B-like) Neighboring gene DUF2250 domain-containing protein Neighboring gene Serpentine Receptor, class BC (Class B-like)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Development and evaluation of an in vivo assay in Caenorhabditis elegans for screening of compounds for their effect on cytochrome P450 expression. Chakrapani BP, et al. J Biosci, 2008 Jun. PMID 18535361
    2. Cytochrome P450-dependent metabolism of eicosapentaenoic acid in the nematode Caenorhabditis elegans. Kulas J, et al. Arch Biochem Biophys, 2008 Apr 1. PMID 18282462
    3. Differential expression of genes in C. elegans reveals transcriptional responses to indirect-acting xenobiotic compounds and insensitivity to 2,3,7,8-tetrachlorodibenzodioxin. Karengera A, et al. Ecotoxicol Environ Saf, 2022 Mar 15. PMID 35219257
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CYtochrome P450 family
    NP_001303718.1
    • Confirmed by transcript evidence
    NP_503594.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      2183488..2186599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071193.4 → NP_503594.1  CYtochrome P450 family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503594.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44706
      Conserved Domains (1) summary
      pfam00067
      Location:26 → 491
      p450; Cytochrome P450

    2. NM_001316789.1 → NP_001303718.1  CYtochrome P450 family [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0M7RF95
      Conserved Domains (1) summary
      cl12078
      Location:1 → 91
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version

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