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    glr-8 Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180924, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glr-8
    Official Full Name
    Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein
    Primary source
    WormBase:WBGene00001619
    Locus tag
    CELE_F22A3.3
    See related
    AllianceGenome:WB:WBGene00001619
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of stimulus involved in sensory perception and monoatomic ion transmembrane transport. Predicted to be located in plasma membrane. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glr-8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (6505980..6509957)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ACT1-like protein Neighboring gene Cation diffusion facilitator family protein 1;Zinc transporter 1 Neighboring gene ncRNA Neighboring gene Transthyretin-like family protein Neighboring gene Transthyretin-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Response of tyramine and glutamate related signals to nanoplastic exposure in Caenorhabditis elegans. Wang S, et al. Ecotoxicol Environ Saf, 2021 Jul 1. PMID 33892344
    2. Functional analysis of Caenorhabditis elegans glutamate receptor subunits by domain transplantation. Strutz-Seebohm N, et al. J Biol Chem, 2003 Nov 7. PMID 12930835
    3. Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42. Brockie PJ, et al. J Neurosci, 2001 Mar 1. PMID 11222641, Free PMC Article
    4. Ionotropic glutamate receptors: genetics, behavior and electrophysiology. Brockie PJ, et al. WormBook, 2006 Jan 19. PMID 18050468, Free PMC Article
    5. Worm watching: imaging nervous system structure and function in Caenorhabditis elegans. Dittman J. Adv Genet, 2009. PMID 19615531

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in detection of stimulus involved in sensory perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein
    NP_001367505.1
    • Confirmed by transcript evidence
    NP_001368711.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6505980..6509957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381010.2 → NP_001367505.1  Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19693, Q9BK18
      Conserved Domains (1) summary
      cd00998
      Location:4 → 366
      PBP2_iGluR_ligand_binding; The ligand-binding domain of ionotropic glutamate receptor family, a member of the periplasmic binding protein type II superfamily

    2. NM_001381009.1 → NP_001368711.1  Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1E9Z6
      Conserved Domains (1) summary
      cd00998
      Location:62 → 424
      PBP2_iGluR_ligand_binding; The ligand-binding domain of ionotropic glutamate receptor family, a member of the periplasmic binding protein type II superfamily
    Nucleotide Protein
    Heading Accession and Version

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